{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:27:04Z","timestamp":1787243224999,"version":"build-2736575974"},"reference-count":38,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"abstract":"<jats:p>Introduction: Active surveillance (AS) is the guideline-recommended management strategy for low-risk and favorable intermediate-risk prostate cancer (PCa). However, conventional risk stratification remains limited in predictive accuracy. Robust real-world evidence on the clinical utility of the cell cycle risk (CCR; Prolaris\u00ae) score within European healthcare settings is currently scarce. Methods: We performed a retrospective single-center study of 60 localized PCa patients who underwent CCR testing at a tertiary academic urologic center between 2021 and 2025. We analyzed indications for testing, CCR treatment recommendations, and adherence rates using descriptive statistics. Results: Median patient age was 62 years, and median prostate-specific antigen level was 5.76 ng\/mL. Overall, 13.3% of biopsy cores were positive, and 93.3% of patients had a Gleason score of 6. CCR testing was performed after initial diagnosis in 61.7% of patients and during ongoing AS in 38.3%. Following CCR testing, definitive therapy was recommended in 21.7% of patients, with an adherence rate of 53.8%, whereas continued AS was recommended in 78.3% of patients, with an adherence rate of 87.2%. Conclusion: CCR testing demonstrated high adherence rates, particularly for AS recommendations in the real-world setting. These findings support Prolaris\u00ae as a complementary decision aid for AS patient selection and management.<\/jats:p>","DOI":"10.1159\/000553659","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:01:04Z","timestamp":1784304064000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Real-World Use of Prolaris\u00ae to Guide Treatment Decisions in Localized Prostate Cancer Eligible for Active 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