{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:58:06Z","timestamp":1791190686828,"version":"4.1.0"},"reference-count":28,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"abstract":"<jats:p>Introduction: The three most common myeloid\/lymphoid neoplasms (MLNs) with eosinophilia and tyrosine kinase gene fusions have rearrangements of the genes coding the alpha and beta subgroups of platelet-derived growth factor receptors (PDGFRA, PDGFRB) and fibroblast growth factor receptor one (FGFR1). The most common partner gene of PDGFRA rearrangement is FIP1L1. However, a few notable exceptions to this have been reported. Case Presentation: In our report, we present the case of a patient with high symptom burden and peripheral blood basophilia who initially went undiagnosed. Then, an unusual PRKG2::PDGFRA translocation with next-generation sequencing panel was detected. Treatment with imatinib led to complete remission. We discuss the clinical presentation, review the literature, and comment on its pathogenesis. Conclusion: In patients with myeloproliferative features, the absence of peripheral blood eosinophilia does not rule out MLN with tyrosine kinase gene fusions. Next-generation sequencing panels that detect RNA fusions may help uncover cryptic or rare fusions. MLN with PDGFRA rearrangement responds well to imatinib.<\/jats:p>","DOI":"10.1159\/aha\/abkag009","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:36:02Z","timestamp":1787657762000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Complete Remission to Imatinib in a Myeloid Neoplasm with Basophilia and PRKG2::PDGFRA Gene Fusion: A Case Report"],"prefix":"10.1159","author":[{"given":"Kirsten A.","family":"Maddox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shefali Tushar","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5783-2049","authenticated-orcid":false,"given":"Shuko","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9226-8001","authenticated-orcid":false,"given":"Diana","family":"Morlote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady M.","family":"Mikhail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-6217","authenticated-orcid":false,"given":"Pankit","family":"Vachhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-695973"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0042"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25945"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.022"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.162"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3182a71eba"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00858-y"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022417"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-286757"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5045\/br.2022.2021138"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01958-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/87.1.66"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899021"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb06186.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2014.01.013"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90311-3"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.253708"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2012.10.015"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02793-4"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20833"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4158567"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000024707"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.53159"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403399"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2026.01.010"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.506"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/aha\/abkag009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:47:06Z","timestamp":1791190026000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/aha\/abkag009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,5]]},"references-count":28,"URL":"https:\/\/doi.org\/10.1159\/aha\/abkag009","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.33320709","asserted-by":"subject"}]},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,5]]}}}