{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:42:49Z","timestamp":1792514569241,"version":"4.5.0"},"reference-count":43,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"abstract":"<jats:p>Introduction: Sepsis is a critical condition with a high nutritional risk and mortality. Although the Global Leadership Initiative on Malnutrition (GLIM) criteria have been proposed for diagnosing malnutrition, their clinical relevance in sepsis remains unclear. Therefore, we conducted a descriptive study on GLIM-defined malnutrition in intensive care unit (ICU) patients with sepsis to investigate its clinical course and prognosis. Methods: This was a multicenter prospective study conducted at 15 centers. Malnutrition was identified at ICU admission when both phenotypic and etiologic criteria were present. The primary outcome was a composite of in-hospital mortality or a decline in activities of daily living (Barthel Index &lt;90) at discharge. Secondary outcomes included ICU length of stay, use of parenteral nutrition, and days to achievement of each ICU Mobility Scale level. Results: Among 254 patients, 106 (41.7%) had malnutrition. The malnutrition group showed a significantly higher occurrence of the composite of in-hospital mortality and Barthel index &lt;90 (76.4% vs. 64.2%, p = 0.04) and had significantly longer ICU stays (7 vs. 5, p = 0.001). Total nutrition delivery did not significantly differ between groups, while a higher percentage of patients in the malnutrition group received parenteral nutrition (57.6% vs. 43.2%, p = 0.02). Significant delays in achieving higher mobility levels were observed in the malnutrition group. Conclusion: GLIM-defined malnutrition in patients with sepsis was significantly associated with the composite outcome of in-hospital mortality or Barthel index &lt;90 at discharge. These results suggest the clinical importance of an early GLIM assessment after ICU admission.<\/jats:p>","DOI":"10.1159\/anm\/abmag005","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:38:58Z","timestamp":1790077138000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Course and Prognosis of the Global Leadership Initiative on Malnutrition-Defined Malnutrition in Critically Ill Patients with Sepsis: A Multicenter Prospective Observational Study"],"prefix":"10.1159","author":[{"given":"Tomoka","family":"Miyagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Suganuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Kariya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Hoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensei","family":"Togo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Obata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenzo","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Heshiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisetsu","family":"Yasumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuko","family":"Gomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Nishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyota","family":"Chinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhei","family":"Irie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kamijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kasugai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Oike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigo","family":"Shimakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Katsukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Kotani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keibun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8481-0294","authenticated-orcid":false,"given":"Kensuke","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06506-y"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2403213"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.415"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17687"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2017.08.008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.08.037"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3390\/nu17030545"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/nu15245040"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12383"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000519642"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12752"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2025.03.011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2590"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2025.04.011"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2022.12.007"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006621"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-025-00792-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-054478"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-021-00555-7"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880141111"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-020-01801-7"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540010086023"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-200203000-00006"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-015-1108-2"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2004.07.005"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.5935\/0103-507X.20200087"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1159\/000521288"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.6133\/apjcn.022017.15"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.59135"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201810-2050CP"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.4266\/acc.2021.01564"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1186\/cc14724"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-025-00785-z"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1159\/000495213"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278481"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000628"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3390\/nu17061073"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2789"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnha.2025.100685"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/anm\/abmag005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:01:06Z","timestamp":1792512066000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/anm\/abmag005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":43,"URL":"https:\/\/doi.org\/10.1159\/anm\/abmag005","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.34029078","asserted-by":"subject"}]},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"value":"0250-6807","type":"print"},{"value":"1421-9697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]}}}