{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:37:12Z","timestamp":1793295432999,"version":"4.5.0"},"reference-count":24,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"abstract":"<jats:p>Introduction: Gastrointestinal (GI) cancers account for a substantial cancer burden, yet contemporary incidence trends and future projections across cancer sites and demographic subgroups remain incompletely characterized. We aimed to analyze incidence trends from 2000 to 2022 and forecast rates through 2032 for eight major GI cancers in the United States. Methods: Using SEER Research Data (17 registries, 2000\u20132022), we identified patients with esophageal, gastric, liver, gallbladder, pancreatic, small intestine, and colorectal cancer (CRC). Crude incidence rates were calculated and stratified by sex, age group (&lt;60 vs. \u226560 years), and race (White, Black, Asian\/Pacific Islander, American Indian\/Alaska Native). Time-series forecasting models (linear regression, ARIMA, ETS [Error, Trend, and Seasonality], neural network autoregressive) were applied to project incidence through 2032. Results: Incidence trends varied markedly by cancer site. Pancreatic cancer showed sustained increases across most subgroups, with projected rates rising from 4.41 to 5.11 per 100,000 by 2032. CRC demonstrated divergent age-specific patterns: incidence among individuals \u226560 years is projected to decline (25.48\u201314.89 per 100,000), while younger age (&lt;60 years) is expected to increase (5.35\u20135.84 per 100,000). Liver cancer incidence is forecast to decline (2.18\u20131.42 per 100,000). Esophageal and gastric cancers showed modest increases, while gallbladder cancer remained stable. Substantial disparities persisted by sex (male predominance for most sites, female predominance for gallbladder) and race (highest burden among Asian\/Pacific Islander populations). Conclusion: GI cancer incidence trajectories are highly heterogeneous. The projected rise in pancreatic and early-onset CRCs signals urgent needs for targeted prevention, risk-factor modification, and improved early detection strategies in at-risk populations.<\/jats:p>","DOI":"10.1159\/ddi\/acnag010","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:38:35Z","timestamp":1790681915000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Incidence Trends and Projections of Major Gastrointestinal Cancers in the United States: A SEER-Based Analysis From 2000 to 2022"],"prefix":"10.1159","author":[{"given":"Said","family":"Yaseen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Khoursheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S.A.","family":"Osman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa","family":"Abdelaziz Abdelmoneim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6665-0778","authenticated-orcid":false,"given":"Basant","family":"Atef Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Hamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allaa Adnan","family":"Khirfan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Saab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Spengler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.10218"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.70017"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20043640"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2009.10.010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12204"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s40471-019-00188-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0109"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19095546"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000549967"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.92613"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.32614\/R.manuals"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.32614\/CRAN.package.forecast"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.14386"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000501745"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare12161645"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v17.i8.107734"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12030288"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i28.6393"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S540103"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-05399-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-024-00592-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-019-0079-0"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2023.103859"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217461"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/ddi\/acnag010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:01:25Z","timestamp":1793293285000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/ddi\/acnag010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":24,"URL":"https:\/\/doi.org\/10.1159\/ddi\/acnag010","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.34153101","asserted-by":"subject"}]},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]}}}