{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:34:55Z","timestamp":1793208895589,"version":"4.5.0"},"reference-count":30,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"abstract":"<jats:p>Introduction: More than 10 years after its introduction into clinical practice, we aimed to assess the current real-life effectiveness and safety of bismuth-containing quadruple therapy in patients infected with Helicobacter pylori. Methods: Consecutive dyspeptic H pylori-positive patients were enrolled, both na\u00efve for treatment and already unsuccessfully treated. Patients received Pylera\u00ae 3 capsules 4 times daily plus omeprazole 20 mg or esomeprazole 40 mg b.i.d. for 10 days. Eradication was confirmed using a urea breath test (at least 30 days after the end of treatment). We assessed the effectiveness and safety of Pylera\u00ae in these patients. Results: A total of 1,018 consecutive patients were included in the study, 648 (63.7%) treated as first-line and 370 (36.3%) treated after failure of at least 1 previous eradication course. The vast majority of patients were fully compliant, except 18 (1.8%) subjects, who discontinued treatment due to severe adverse events. Helicobacter pylori eradication was achieved in 959\/1,000 (95.9%, CI 94.7%\u201397.1%) patients, higher in na\u00efve than in previously treated patients (97.3%, CI 96.1%\u201398.6%, vs. 93.3%, CI 90.8%\u201395.9%; p = 0.002). Overall, the eradication rate remains significantly high during the observational period. In particular, it was 100% in 2020, 97.8% (CI 95.7%\u201399.9%) in 2021, 100% in 2022, 98.8% (CI 97.3%\u2013100%) in 2023, 89.1% (CI 84.6%\u201393.6%) in 2024, and 97.8% (CI 95.5%\u2013100%) in 2025: the failures, although minimal, were more present in 2024 (p &lt; 0.001). Finally, the eradication rate remained constant from 2020 to 2025. Conclusions: Pylera\u00ae remains an effective and safe therapeutic option for curing H pylori infection in both na\u00efve and previously treated patients.<\/jats:p>","DOI":"10.1159\/ddi\/acnag012","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:27:32Z","timestamp":1791113252000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Is Pylera\u00ae Still Effective and Safe in Patients Infected by Helicobacter pylori? A 6-Year, Multicentre, Real-Life Study"],"prefix":"10.1159","author":[{"given":"Francesco","family":"Di Mario","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilisa","family":"Franceschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Elisei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pellegrino","family":"Crafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Picchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-5541","authenticated-orcid":false,"given":"Antonio","family":"Tursi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.06.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-015-0245-y"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002968"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.t01-1-07288.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60020-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12808"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2015.12.012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12371"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000487391"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.17235\/reed.2017.4809\/2016"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332804"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12569"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.1.8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-7-199810010-00007"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.012"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.007"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-5617"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12659"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.10.009"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001102"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12606"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.667584"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13040348"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001246"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e318217605f"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/ddi\/acnag012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:01:45Z","timestamp":1793206905000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/ddi\/acnag012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":30,"URL":"https:\/\/doi.org\/10.1159\/ddi\/acnag012","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]}}}