{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:51:53Z","timestamp":1791564713373,"version":"4.3.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"abstract":"<jats:p>Introduction: Informant reports are thought helpful for Alzheimer's disease (AD) diagnosis. We hypothesized that informants would improve diagnostic accuracy, operationalized as agreement between clinical impression and amyloid PET (aPET) findings. Methods: This study was a retrospective analysis of 168 Veterans referred for aPET due to diagnostic uncertainty or atypical presentation (Mage=69.3, SD=5.8). We examined the association between diagnostic accuracy and presence of an informant, patient's MoCA score, and informant type. Results: We found no evidence that informant presence was associated with diagnostic accuracy (OR = 0.92, 95% CI 0.48, 1.72), that this association varied by patient cognitive status as measured by MoCA (interaction OR = 1.13, 95% CI 0.97, 1.33), or that diagnostic accuracy differed by informant type (spouse\/partner: OR = 1.23, 95% CI 0.55, 2.79; other: OR = 0.91, 95% CI 0.29, 2.71). Conclusion: Our findings suggest informant presence does not necessarily enhance diagnostic accuracy for complex AD presentations. This highlights the continued value of aPET imaging in complex clinical presentations.<\/jats:p>","DOI":"10.1159\/dem\/aciag009","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:26:02Z","timestamp":1789673162000},"source":"Crossref","is-referenced-by-count":0,"title":["Informant Presence Fails to Enhance Alzheimer\u2019s Diagnosis in Complex Veteran Cases"],"prefix":"10.1159","author":[{"given":"Maureen K.","family":"O&apos;Connor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0548-9074","authenticated-orcid":false,"given":"Brandon","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah H","family":"Noah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha K.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily E","family":"Metcalf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"DeCaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Vives-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7830-0780","authenticated-orcid":false,"given":"Brenna","family":"Hagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Atlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landon","family":"Hurley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine W","family":"Turk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2913-0015","authenticated-orcid":false,"given":"Andrew E.","family":"Budson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,10,9]]},"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/dem\/aciag009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:01:23Z","timestamp":1791561683000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/dem\/aciag009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/dem\/aciag009","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.34227900","asserted-by":"subject"}]},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]}}}