{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:52:58Z","timestamp":1791359578481,"version":"4.3.1"},"reference-count":46,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"abstract":"<jats:p>Introduction: There is limited and conflicting data regarding the risk of thyroid, kidney, and prostate cancers in patients with inflammatory bowel disease (IBD). Methods: This was a retrospective cohort study using the US Collaborative Network comparing the risk of thyroid, kidney, and prostate cancer in IBD compared to non-IBD (control) cohort. One-to-one propensity score matching was performed for demographics and comorbid conditions. Cox proportional hazard model was used to identify risk factors for each cancer. Results: There were 200,280 matched pairs in the IBD and control cohorts (mean age 43.7 \u00b1 19.5 years, 46.1% male, 76% white). Compared with non-IBD controls, patients with IBD had increased odds of thyroid cancer (aOR 1.37, 95% CI: 1.19\u20131.59), kidney cancer (aOR 1.37, 95% CI: 1.22\u20131.54), and prostate cancer (aOR 1.39, 95% CI: 1.29\u20131.51). These associations were generally consistent across IBD subtypes and sex strata. Racial\/ethnic disparities were observed for each cancer. Patients with IBD aged 18\u201339 years had increased odds of thyroid cancer (aOR 1.41, 95% CI: 1.08\u20131.84), but not kidney or prostate cancer, compared with controls. Long-term systemic steroid use was associated with increased risk of thyroid cancer (HR 1.75, 95% CI: 1.29\u20132.36) and kidney cancer (HR 1.52, 95% CI: 1.24\u20131.87), while type 2 diabetes mellitus and obesity were associated with increased risk of all three cancers in the IBD cohort. Conclusion: In this focused analysis of selected extraintestinal solid organ malignancies, IBD was associated with increased risk of thyroid, kidney, and prostate cancer. These findings support further research into cancer-specific mechanisms, surveillance patterns, and risk stratification in patients with IBD.<\/jats:p>","DOI":"10.1159\/dig\/acmag010","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:48:54Z","timestamp":1787312934000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Risk of Extraintestinal Solid Organ Malignancy in Patients with Inflammatory Bowel Disease: A Propensity-Matched Cohort Study"],"prefix":"10.1159","author":[{"given":"Aakash","family":"Desai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Chowdhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himsikhar","family":"Khataniar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis 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