{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:55:20Z","timestamp":1791190520531,"version":"4.1.0"},"reference-count":32,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"abstract":"<jats:p>Introduction: Pemphigus vulgaris (PV) is an autoimmune blistering dermatosis affecting both sexes. Previous studies suggest an increased cardiovascular risk in PV patients, though the underlying mechanisms remain unclear. Methods: This case-control study evaluated carotid intima-media thickness (CIMT) via ultrasonography as a marker of subclinical atherosclerosis in PV. Seventy patients were categorized based on disease duration (&lt;1 year and 1\u20134 years) and compared to 35 age- and gender-matched healthy controls. Data on demographics, Pemphigus Disease Area Index (PDAI), and total rituximab (RTX) dosage were collected. Results: Age was significantly correlated with CIMT in all groups. Although left and right plaque presence was significant in controls (p = 0.007), no significant plaque burden was observed in either patient group. CIMT showed a significant positive correlation with waist circumference in the &lt;1-year group and controls (p = 0.027 and p = 0.001, respectively) and with BMI in the &lt;1-year group. PDAI was significantly associated only with left CIMT in patients with 1\u20134 years of disease (p = 0.035). Additionally, male patients in the 1\u20134-year group had significantly higher left and right CIMT (p = 0.014 and p = 0.047, respectively). No significant differences in CIMT size or plaque presence were observed between patient and control groups. Conclusion: These findings suggest that age, gender, BMI, waist circumference, and disease severity may contribute to subclinical atherosclerosis in PV, with plaque formation potentially linked to persistent inflammation.<\/jats:p>","DOI":"10.1159\/drm\/ackag011","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:48:52Z","timestamp":1787226532000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Investigating Atherosclerosis through Ultrasonographic Assessment of Carotid Intima-Media Thickness in Pemphigus Vulgaris: A Case-Control Study"],"prefix":"10.1159","author":[{"given":"Shahin","family":"Hamzelou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Khorasanizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Daneshpazhooh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Aryanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safoura","family":"Shakoei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Omid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sama","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Homayouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/s41702-017-0008-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101080"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20199011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_205_17"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.21315\/mjms2020.27.2.7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13474"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4103\/0300-1652.170384"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-012-0306-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14236"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-018-0112-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.01.009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.04.026"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-022-02346-y"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.14744\/nci.2020.37039"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S75908"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2013.06.002"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09474.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.6515\/ACS.201901_35(1).20180628A"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-020-02084-z"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.025"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14803"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv759"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206624"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.06.019"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2019.07.004"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.214585"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.812631"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-016-0578-8"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13628"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13217"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.12.005"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12068"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/drm\/ackag011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:30:26Z","timestamp":1791189026000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/drm\/ackag011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":32,"URL":"https:\/\/doi.org\/10.1159\/drm\/ackag011","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]}}}