{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:41:49Z","timestamp":1792428109965,"version":"4.5.0"},"reference-count":28,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Folia Phoniatr Logop"],"abstract":"<jats:p>Introduction: Although HRM is widely considered a well-tolerated and minimally invasive procedure, pain and anxiety are reported by patients. We aimed to investigate whether patient-reported and physiologic indicators of procedure-related pain and anxiety are associated with high-resolution manometry (HRM) findings at rest and during swallowing. Methods: HRM data and patient-reported measures and physiologic indicators of pain and anxiety were collected from 36 outpatient adults. Multivariable linear regression models were used to assess the associations between pain\/anxiety and upper esophageal sphincter (UES)\/lower esophageal sphincter pressures and esophageal motility outcomes. Predictor variables included (1) a validated visual analogue scale (VAS) of self-reported pain; (2) the State Trait Anxiety Inventory (STAI) sum score; (3) the Short-Form McGill Pain Questionnaire (SFMPQ); (4) heart rate before the procedure (HR); and (5) average slope of galvanic skin response (GSRslope). Relationships were assessed both at rest for basal measures and during swallowing for peristaltic measures. Results: Few statistically significant relationships were observed between patient-reported measures or physiologic indicators of anxiety\/pain with esophageal or sphincter measures. However, UES mean residual pressure during swallowing was negatively associated with VAS pain ratings (p = 0.04) and the GSRslope (p = 0.01). Additionally, as SF-MPQ increased, the percentage of intact swallows decreased (adjusted R2 = 0.146; p = 0.012). Conclusion: UES resting pressure during HRM procedures was not significantly associated with patient-reported anxiety or pain. However, we saw a small statistically significant inverse association between UES mean residual pressure and patient-reported pain and physiologic arousal (GSRslope). Future research may benefit from continuous physiologic monitoring throughout HRM procedures and from inclusion of a larger sample with more diverse pathology.<\/jats:p>","DOI":"10.1159\/fpl\/acvag016","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:53:27Z","timestamp":1789041207000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Patient-Reported and Physiologic Markers of Pain and Anxiety during High-Resolution Manometry: An Exploratory Study"],"prefix":"10.1159","author":[{"given":"Sarah","family":"Stewart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Mocchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Palte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Schnoll-Sussman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Soumekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasa","family":"Zarnegar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-2634","authenticated-orcid":false,"given":"Ana\u00efs","family":"Rameau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1044\/2018_AJSLP-18-0039"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-013-9494-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-019-10023-y"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000571"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14167"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2050.2002.00224.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536159"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90915-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.5056\/jnm16119"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90400-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-196203000-00007"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1987.tb00265.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.08.016"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd015458"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.11.032"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.70276"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30914"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8260.1992.tb00997.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(87)91074-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/s21124210"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14058"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1044\/2020_JSLHR-19-00299"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-67202014000300005"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(15)32752-9"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S337165"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1177\/0003489414522975"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1177\/26345161211072761"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420966339"}],"container-title":["Folia Phoniatrica et Logopaedica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/fpl\/acvag016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:01:34Z","timestamp":1792425694000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/fpl\/acvag016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":28,"URL":"https:\/\/doi.org\/10.1159\/fpl\/acvag016","archive":["Portico"],"relation":{},"ISSN":["1021-7762","1421-9972"],"issn-type":[{"value":"1021-7762","type":"print"},{"value":"1421-9972","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]}}}