{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:41:14Z","timestamp":1792428074173,"version":"4.5.0"},"reference-count":30,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"abstract":"<jats:p>Background: Endometrial thickness is a significant determinant of pregnancy outcomes following in vitro fertilization embryo transfer (IVF-ET). However, the relationship between endometrial thickness and the risk of ectopic pregnancy after IVF-ET remains debated. Methods: We conducted a comprehensive literature search of the PubMed, Cochrane Library, and Embase databases to identify relevant studies. In fresh embryo transfer cycles, endometrial thickness was measured on the day of hCG triggering; in frozen-thawed embryo transfer cycles, measurement was performed during the endometrial preparation phase prior to embryo transfer. The ectopic pregnancy rate was designated as the primary outcome measure. Pairwise meta-analyses were performed using Review Manager 5.3. Results: A total of ten studies met the inclusion criteria. In the meta-analysis, women with a thin endometrium undergoing IVF-ET had a significantly higher risk of ectopic pregnancy compared with those with a non-thin endometrium (odds ratio [OR] 2.27, 95% confidence interval [CI] 1.78\u20132.91, I2 = 48%). Subgroup analyses showed consistent findings in both fresh embryo transfer (OR 2.58, 95% CI 1.62\u20134.10, I2 = 23%) and frozen-thawed embryo transfer cycles (OR 2.16, 95% CI 1.61\u20132.89, I2 = 60%). When thin endometrium was defined as &lt;7 mm or &lt;8 mm, the risks remained elevated (OR 2.00 and 2.36, respectively). Conclusion: In IVF-ET cycles, a thin endometrium is associated with a significantly increased ectopic pregnancy rate. No optimal thickness range can be identified from the available data due to the lack of individual patient information and the absence of dose-response analyses.<\/jats:p>","DOI":"10.1159\/goi\/aczag006","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T11:33:32Z","timestamp":1787484812000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Endometrial Thickness and Ectopic Pregnancy Risk following in vitro Fertilization Embryo Transfer: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","author":[{"given":"MeiFang","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BaoPing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19411"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2023.103259"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.12.025"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.02.041"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1136616"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.09.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.05.033"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac148"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1040140"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.02.013"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.04.031"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002464"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0296497"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-023-05920-y"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-023-05837-6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1259608"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2022.2109141"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.09.003"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1066922"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.05.002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-016-0222-5"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.12.016"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2020.1821359"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4724-6"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2020.03.015"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11123386"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05353-z"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2020.1742686"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.07.1096"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/goi\/aczag006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:01:25Z","timestamp":1792425685000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/goi\/aczag006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,10]]},"references-count":30,"URL":"https:\/\/doi.org\/10.1159\/goi\/aczag006","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.33295767","asserted-by":"subject"}]},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,10]]}}}