{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:48:00Z","timestamp":1791823680689,"version":"4.3.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"abstract":"<jats:p>Background: Obesity influences nearly 30% of the world population, and is closely related to uterine cancer. This study aims to explore the burden obesity-related uterine cancer and cross-country inequalities across sociodemographic development levels with Global Burden of Diseases 2021 (GBD 2021). Materials and methods: The study analyzed trends of deaths, disability-adjusted life years (DALY), years of life lost (YLL) of obesity-related uterine cancer utilizing age-standardized rates and their average annual percentage changes (AAPCs). Decomposition, cross-country inequality, and predictive analysis were also performed. Results: The global burden of obesity-related uterine cancer increased by 138.49% in deaths, 136.19% in DALY, and 129.61% in YLL from 1990 to 2021. Globally, population growth had the greatest impact on increased DALY between 1990 and 2021, accounting for 46.49%, followed by 40.07% of aging and 13.44% of epidemiologic changes. The slope index of inequality indicated that the gap in DALYs between countries with the highest and lowest sociodemographic index (SDI) increased from 30.05 (95%CI 25.27 to 34.65) in 1990 to 48.49 (95%CI 38.58 to 58.91) in 2021. The concentration index remained stable from 0.49 (95%CI 0.41 to 0.56) in 1990 to 0.41 (95%CI 0.34 to 0.48) in 2021 (p = 0.175). The total DALY is expected to more than double, reaching 1,837,036 in 2050 with age-standardized DALY rate is expected to increase slightly by 2050. Conclusion: The burden of obesity-related uterine cancer is rising rapidly, disproportionately affecting higher-SDI countries, with widening absolute but largely stable relative socioeconomic inequalities. Projections from 2020 to 2050 indicate a steady increase in both cases and age-standardized rates. Weight control is crucial for mitigating the burden of obesity-related uterine cancer.<\/jats:p>","DOI":"10.1159\/goi\/aczag015","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:25:12Z","timestamp":1791199512000},"source":"Crossref","is-referenced-by-count":0,"title":["Global burden, cross-country inequalities, and projection of obesity-related uterine cancer"],"prefix":"10.1159","author":[{"given":"Guanchen","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,10,12]]},"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/goi\/aczag015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:02:24Z","timestamp":1791820944000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/goi\/aczag015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/goi\/aczag015","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.34311297","asserted-by":"subject"}]},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]}}}