{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:47:02Z","timestamp":1791996422671,"version":"4.4.0"},"reference-count":12,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Introduction: Fruit and vegetable allergies in childhood present with heterogeneous clinical features and are often influenced by cross-reactivity with aeroallergens. Despite their growing clinical importance, data on diagnostic accuracy and clinical phenotypes remain limited, particularly in regions where component-resolved diagnostic tests are not available. Methods: This 5-year retrospective cohort study evaluated children aged 0\u201318 years who presented to a tertiary pediatric allergy clinic between 2020 and 2025 with suspected fruit or vegetable allergy. Clinical history, skin prick test (SPT), specific IgE (sIgE), prick-by-prick test results, aeroallergen sensitization profiles, laboratory parameters, and oral food challenge (OFC) outcomes were reviewed. Only patients whose diagnoses were confirmed by OFC were included in the study. Results: A total of 19 OFC-confirmed cases were included. The median age at symptom onset was 41.5 months. Based on the total number of triggering foods (n = 23), the most common allergens were kiwi (17.4%) and strawberry (17.4%), while urticaria was the most frequent clinical manifestation at initial presentation (52.2%). Reaction types did not significantly differ across different allergen subgroups; however, patients with oral allergy syndrome had a significantly higher age of symptom onset (p = 0.002). Sensitization tests demonstrated limited diagnostic performance for predicting OFC-confirmed fruit and vegetable allergy, with a sensitivity of 47.4%, a specificity of 80.0%, a positive predictive value of 52.9%, a negative predictive value of 76.2%, and an overall diagnostic accuracy of 69.5%. Conclusions: Fruit and vegetable allergies in childhood are generally mild but may exhibit considerable clinical variability. Skin prick test and serum-specific IgE tests alone are insufficient for diagnosis, and OFC remains the gold standard for diagnostic confirmation. Larger, multi-center studies are needed to better characterize sensitization patterns and to establish reliable diagnostic cut-off values.<\/jats:p>","DOI":"10.1159\/iaa\/adfag005","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:27:12Z","timestamp":1786706832000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Laboratory Characteristics of Fruit and Vegetable Allergy in Childhood: A Five-Year Retrospective Evaluation"],"prefix":"10.1159","author":[{"given":"Asl\u0131 Berivan","family":"Top\u00e7ak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Karaca \u015eahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilay","family":"\u00c7al\u0131\u015fkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcler","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamit","family":"Bologur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"G\u00fcng\u00f6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Fatih","family":"Erbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Tun\u00e7","family":"\u015earman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7a\u011fla","family":"\u00d6zt\u00fcrk Turan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer Y\u0131lmaz","family":"Uluta\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eule","family":"Papa\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefika Ilknur","family":"K\u00f6kc\u00fc Karadag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0032-6727","authenticated-orcid":false,"given":"Deniz","family":"Ozceker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.019"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13854"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0091"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/all.15902"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2022.03.019"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.03.042"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/pai.14276"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-016-2357-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000539216"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2024.08.007"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/all.12666"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/iaa\/adfag005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:03:51Z","timestamp":1791993831000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/iaa\/adfag005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":12,"URL":"https:\/\/doi.org\/10.1159\/iaa\/adfag005","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.33142709","asserted-by":"subject"}]},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,3]]}}}