{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:41:50Z","timestamp":1792428110044,"version":"4.5.0"},"reference-count":20,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Introduction: The objectives of the study were to evaluate age-related differences in asthma diagnosis and management among children hospitalized for moderate-to-severe asthma exacerbations and to examine the relationship of regular follow-up and home-based exacerbation management with clinical outcomes. Methods: This retrospective observational study included children aged 25 months to &lt;18 years who were hospitalized for moderate-to-severe asthma exacerbations. Patients were categorized as preschool-aged (25\u201360 months) or school-aged (61 months to &lt;18 years). Asthma diagnosis before hospitalization, regular follow-up, controller therapy use, caregiver education, initiation of home-based treatment, exacerbation history, and healthcare utilization were compared. Results: A total of 104 children were included. Preschool children were less likely than school-aged children to have received an asthma diagnosis before hospitalization (56.5% vs. 83.3%, p = 0.008) and were more frequently managed with diagnoses such as bronchiolitis or bronchitis. Antibiotic use before asthma diagnosis was reported in 87.5% of the cohort. Patients attending regular follow-up had higher rates of controller therapy use, home-based exacerbation management education, and initiation of treatment at home (all p &lt; 0.001). They also had fewer moderate-to-severe exacerbations (p &lt; 0.001) and fewer emergency department visits (p = 0.036). Although children initiating home treatment had a greater previous exacerbation burden, they had fewer moderate-to-severe exacerbations during the preceding year than those who did not initiate treatment at home (p = 0.004). In multivariable analysis, regular follow-up remained independently associated with lower odds of recurrent moderate-to-severe exacerbations (aOR 0.03, 95% CI: 0.004\u20130.20; p &lt; 0.001). Conclusion: Asthma was less often recognized before hospitalization in preschool children, and antibiotic use before diagnosis was common. Children attending regular follow-up more often received controller therapy and home-management education and had fewer moderate-to-severe exacerbations and emergency department visits. These findings highlight the importance of timely asthma recognition, regular follow-up, and practical caregiver education in children with recurrent wheezing or asthma, while the observational design precludes causal inference.<\/jats:p>","DOI":"10.1159\/iaa\/adfag018","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:23:22Z","timestamp":1789673002000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Age-Related Differences in Asthma Recognition, Follow-Up and Home-Based Exacerbation Management among Children Hospitalized for Acute Asthma Exacerbations"],"prefix":"10.1159","author":[{"given":"Seyma","family":"Butun Turk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alp","family":"Kazancioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ipek","family":"Turktas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.070169"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.05.004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h996"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.02.011"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-323496"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.10.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2025.100409"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2018.02.006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-20"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6364194"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2024.10.036"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008469.pub3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2020.1731824"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-11-32"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-27.4.366"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/all.70091"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00111.2014"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30304-9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacig.2025.100415"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1177\/30502225251325625"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/iaa\/adfag018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:01:32Z","timestamp":1792425692000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/iaa\/adfag018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,10]]},"references-count":20,"URL":"https:\/\/doi.org\/10.1159\/iaa\/adfag018","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,10]]}}}