{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:55:21Z","timestamp":1791190521173,"version":"4.1.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Background Shrimp allergy is a prevalent, although data from Northern Europe are limited. This study evaluated oral food challenge (OFC)-verified shrimp allergy and the relationship between shrimp and house dust mite (HDM)-sensitizations in patients suspected of shrimp allergy. Methods Patients undergoing OFC to shrimp between 2002 and 2024 were retrospectively included (n=324). Clinical OFC data, skin prick-prick tests (SPT), serum-specific immunoglobulin E (s-IgE) to shrimp and HDM (Dermatophagoides pteronyssinus, Dermatophagoides farinae), and demographics were analyzed. Risk factors for positive OFC were evaluated using multivariate logistic regression. Results Shrimp allergy (all shrimp-types) was confirmed by OFC in 12.3% (n=40), with a higher prevalence in children\/adolescents (\u226417 years) than in adults (22.8% vs 8.2%, p&lt;0.001). The median cumulative eliciting dose was 18.8 grams (interquartile range: 8.8-48.8). Reactions were predominantly cutaneous, mucosal, and gastrointestinal; 10% developed anaphylaxis. Patients allergic to Northern Shrimp (positive OFC) more frequently had positive SPT to shrimp (23.7% vs 4.7%, p&lt;0.001) and trended toward higher shrimp-specific s-IgE. Sensitization to HDM was more frequent in shrimp-allergic than tolerant patients (68.6% vs 46.6%, p=0.013). A stronger response to shrimp than HDM (difference in SPT &gt;1 mm or s-IgE &gt;1 kUA\/L) was associated with positive OFC. Mono-sensitization to shrimp (odds ratio (OR)=6.41), concomitant shrimp and HDM sensitization (OR=8.89), and age \u226417 years (OR=0.27) were independent risk factors for a positive OFC. Conclusion Shrimp allergy was confirmed by OFC in 12% of suspected cases evaluated at a tertiary allergy centre. Cross-reactivity with HDM may impair the diagnostic accuracy of conventional allergy tests, highlighting the need for improved in vitro-diagnostics.<\/jats:p>","DOI":"10.1159\/iaa\/adfag027","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:52:34Z","timestamp":1789127554000},"source":"Crossref","is-referenced-by-count":0,"title":["Challenge-verified shrimp allergy in a Danish patient cohort throughout 23 years"],"prefix":"10.1159","author":[{"given":"Sebastian Vigand","family":"Svendsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Bindslev-Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Gotthard","family":"Mortz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,9,11]]},"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/iaa\/adfag027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:30:41Z","timestamp":1791189041000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/iaa\/adfag027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/iaa\/adfag027","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]}}}