{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:42:31Z","timestamp":1792514551464,"version":"4.5.0"},"reference-count":25,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"abstract":"<jats:p>Introduction: The timing of tolerance acquisition in childhood IgE-mediated food allergy is clinically important but has been less well studied than persistence as a binary outcome. We examined clinical and immunological determinants of time to open oral food challenge (OFC)-confirmed tolerance. Methods: This retrospective cohort study included 157 children with physician-established IgE-mediated food allergy evaluated at a tertiary pediatric allergy clinic between January 2023 and July 2026. Time zero was defined as elimination-diet initiation; tolerance was defined exclusively by a successful supervised open OFC. One mutually exclusive index allergen was assigned to each child and used consistently to define the time-to-tolerance outcome. Kaplan-Meier analysis and parametric accelerated failure time (AFT) models were used. The log-logistic model, adjusted for index allergen and the prespecified clinical and immunological covariates, was selected for multivariable analysis and internally validated using 1,000 bootstrap resamples. Results: Of 157 children, 120 achieved OFC-confirmed tolerance and 37 were right-censored. The mutually exclusive index-allergen distribution was hen\u2019s egg (n = 103), cow\u2019s milk (n = 35), tree nut (n = 16), other food (n = 2), and fish (n = 1). In the index-allergen-adjusted log-logistic AFT model, food-induced anaphylaxis (adjusted time ratio [TR]: 2.13, 95% CI: 1.34\u20133.36; p = 0.001), allergic rhinitis (adjusted TR: 1.80, 95% CI: 1.26\u20132.55; p = 0.001), and each 10-fold increase in total IgE (adjusted TR: 1.54, 95% CI: 1.20\u20131.98; p &lt; 0.001) were associated with a longer time to tolerance. Tree-nut index allergy was also associated with longer time to tolerance than hen\u2019s egg (adjusted TR: 2.74, 95% CI: 1.19\u20136.29; p = 0.018), although this estimate was based on few tolerance events. Conclusion: Previous food-induced anaphylaxis, allergic rhinitis, higher total IgE, and index food type were associated with the timing of open OFC-confirmed tolerance in children with IgE-mediated food allergy. Routine quantitative IgG, IgA, and IgM measures were not independently associated with tolerance timing.<\/jats:p>","DOI":"10.1159\/iaa\/adfag028","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:22:22Z","timestamp":1789672942000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Immunological Determinants of Time to Open Oral Food Challenge-Confirmed Tolerance in Children with IgE-Mediated Food Allergy: A Retrospective Cohort Study"],"prefix":"10.1159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3393-489X","authenticated-orcid":false,"given":"\u00d6zge","family":"Kangall\u0131 Boyac\u0131o\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zgen","family":"Soy\u00f6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semiha","family":"Erdem Bah\u00e7eci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-020-0898-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/pai.14108"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.04.008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.10.060"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1041"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13370"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.06.017"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/all.15902"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/all.15939"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/pai.14276"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.09.029"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.12.991"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2023.02.004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/all.16345"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2022.104650"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13368"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/nu17061014"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2024.102493"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60010021"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23090"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01261-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2024.16.2.179"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2024.100904"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.09.024"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.09.044"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/iaa\/adfag028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:01:29Z","timestamp":1792512089000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/iaa\/adfag028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":25,"URL":"https:\/\/doi.org\/10.1159\/iaa\/adfag028","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.34068666","asserted-by":"subject"}]},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]}}}