{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:51:54Z","timestamp":1791564714703,"version":"4.3.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"abstract":"<jats:p>Background: Hemodynamic alterations in microvessels under pathological conditions such as cancer can modify RBC dynamics and near-wall behavior, influencing the cell-free layer and local flow microenvironment. Methods: Three-dimensional simulations of two red blood cells with different stiffness levels were performed in venular flow under conditions representing a healthy individual and a breast cancer patient. The simulations were carried out using a force-coupling immersed-boundary lattice Boltzmann framework. RBC deformation, longitudinal and radial migration, velocity distribution, shear rate, and pressure fields were analyzed using hematocrit data, with blood viscosity derived from these data. Results: Compared with healthy flow, cancer-affected conditions led to reduced RBC deformation and diminished radial migration, resulting in increased near-wall residence. This effect was more pronounced for the stiffened RBC. It was accompanied by a local reduction in near-wall velocity, an increase in shear rate, and larger pressure differences across the cell. Shear rate was higher in cancer-affected flow, while near-wall variations were reduced. Conclusions: The results indicate that cancer-associated changes in venular flow promote RBC near-wall localization and may suppress CFL formation, primarily due to reduced RBC deformation, overriding low-hematocrit dilution. Circulating tumor cells were not modeled; however, RBC dynamics suggest a microenvironment that may facilitate near-wall interactions.<\/jats:p>","DOI":"10.1159\/jvr\/adiag007","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:57:43Z","timestamp":1790769463000},"source":"Crossref","is-referenced-by-count":0,"title":["Red Blood Cell Dynamics in Healthy and Cancer-Influenced Venular Flow: Role of Flow Conditions and Cell Stiffness"],"prefix":"10.1159","author":[{"given":"Tahereh","family":"Zarei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Aghanajafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Soltani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,10,9]]},"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/jvr\/adiag007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:01:50Z","timestamp":1791561710000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/jvr\/adiag007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/jvr\/adiag007","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.34157367","asserted-by":"subject"}]},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"value":"1018-1172","type":"print"},{"value":"1423-0135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]}}}