{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:57:34Z","timestamp":1791190654830,"version":"4.1.0"},"reference-count":27,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"abstract":"<jats:p>&lt;p&gt;Objective: We evaluated the clinicopathological correlations of maternal serum free beta-human chorionic gonadotropin (FBHCG)\/pregnancy-associated plasma protein A (PAPP-A) multiple of the median ratio measured between 11 + 0 and 13 + 6 weeks of gestation, pregnancy characteristics, and placental histopathology in pregnancies affected by fetal growth restriction (FGR). Subjects and Methods: We investigated 69 pregnancies complicated with FGR. Different indicators of FGR, placental villous capillarization, placental weight to birth weight ratio, and placental histopathological entities were correlated with FBHCG\/PAPP-A ratio. Results: Complication of FGR with preeclampsia (p &lt; 0.001) and birth weight below the 2nd percentile (p &lt; 0.001) were significantly more common when the FBHCG\/PAPP-A ratio was higher. Placental weight to birth weight ratio was significantly lower (&lt;1:8) in cases of higher FBHCG\/PAPP-A ratio. Distal villous hypoplasia (DVH), avascular villi (AV), and chorangiosis were more prevalent in cases with a higher FBHCG\/PAPP-A ratio; however, villous capillarization, onset of FGR, oligohydramnios, and preterm birth did not have an association with it. Conclusion: In FGR, a higher FBHCG\/PAPP-A ratio could be an early indicator of placental villous underdevelopment, which is further supported by the fact that higher prevalence of DVH and AV was described in cases with a higher FBHCG\/PAPP-A ratio. We conclude that this ratio could be an early marker of potential placental dysfunction (and consecutive FGR later in pregnancy), rendering it a helpful marker as early as the end of the first trimester for identifying pregnancies that warrant close monitoring throughout gestation.&lt;\/p&gt;<\/jats:p>","DOI":"10.1159\/mpp\/adpag002","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:01:22Z","timestamp":1786021282000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Correlations of Free Beta-Human Chorionic Gonadotropin\/Pregnancy-Associated Plasma Protein A Ratio, Pregnancy Characteristics, and Placental Pathology in Fetal Growth Restriction"],"prefix":"10.1159","author":[{"given":"Istv\u00e1n","family":"Dank\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Tank\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edit","family":"Kelemen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9la","family":"Temesv\u00e1ry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Cserni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.02.007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4341-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i13.2855"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.33919"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/pd.105"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3809"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-024-03105-z"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/pd.407"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3947-z"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000359969"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14870"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/15513819609168713"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0225-CC"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.12703\/b\/9-10"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14070698"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.12865\/CHSJ.45.03.14"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2014.06.022"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14555"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17395"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12072502"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.024"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.023"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147886"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000448949"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200109000-00001"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2019.07.004"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/734865"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/mpp\/adpag002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:47:41Z","timestamp":1791190061000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/mpp\/adpag002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":27,"URL":"https:\/\/doi.org\/10.1159\/mpp\/adpag002","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]}}}