{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:44:12Z","timestamp":1792514652501,"version":"4.5.0"},"reference-count":27,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"abstract":"<jats:p>Objective: The objectives of the study were to compare clinical efficacy, hemodynamic stability, and 90-day renal outcomes between sustained low-efficiency dialysis (SLED) and intermittent hemodialysis (IHD) in medical intensive care unit (MICU) patients with severe acute kidney injury (AKI). Methods: This observational cohort study evaluated 300 patients with KDIGO Stage-2 or 3 AKI (SLED: n = 160; IHD: n = 140). Outcomes included MICU mortality, discharge renal recovery, stay duration, intradialytic complications, and 90-day renal preservation. Results: Baseline characteristics were comparable. No significant differences emerged between SLED and IHD regarding MICU mortality (33% vs. 39%, p = 0.272) or renal recovery at discharge (61% vs. 54%, p = 0.223). However, SLED demonstrated superior safety, significantly lowering intradialytic hypotension (21% vs. 41%, p &lt; 0.001) and the need for new vasopressors (11% vs. 22%, p = 0.011), while minimizing mean arterial pressure drops (12.12 \u00b1 3.9 vs. 19 \u00b1 6.36 mm Hg, p &lt; 0.001). SLED achieved shorter median MICU stays (14 vs. 16 days, p &lt; 0.001). At 90-day, SLED survivors exhibited significantly lower renal replacement therapy dependence (11% vs. 24%, p = 0.014), reduced chronic kidney disease progression (26% vs. 34%, p = 0.044), and higher glomerular filtration rate (55.93 \u00b1 7.69 vs. 45.86 \u00b1 9.29 mL\/min\/1.73 m2, p &lt; 0.001). Conclusions: While short-term mortality is similar, SLED dramatically mitigates intradialytic hemodynamic instability compared to IHD. By minimizing circulatory insults, SLED significantly improves 90-day parenchymal renal recovery and minimizes long-term dialysis dependence among AKI survivors.<\/jats:p>","DOI":"10.1159\/mpp\/adpag017","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:18:57Z","timestamp":1788520737000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Sustained Low-Efficiency Dialysis versus Intermittent Hemodialysis in Critically Ill Patients with Severe Acute Kidney Injury"],"prefix":"10.1159","author":[{"given":"Xixi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02385-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00293-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-025-02234-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-025-08015-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00519-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.06.028"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2504015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.02.033"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.88678"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2580065"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2026.2624275"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000045094"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1515\/med-2023-0868"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.54376"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006616"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2025.155103"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0320351"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-025-08008-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2020.11.003"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06454-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2025.155076"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05693-0"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13854"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-84435-8"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061704"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00284-z"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-024-02201-5"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/mpp\/adpag017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:01:48Z","timestamp":1792512108000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/mpp\/adpag017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,5]]},"references-count":27,"URL":"https:\/\/doi.org\/10.1159\/mpp\/adpag017","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.33393736","asserted-by":"subject"}]},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,5]]}}}