{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:58:15Z","timestamp":1791190695657,"version":"4.1.0"},"reference-count":31,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"abstract":"<jats:p>Introduction: The incidence of multiple sclerosis (MS) has shown varying temporal trends across European countries in recent decades, particularly in high-incidence areas. We aimed to describe the incidence risks and temporal trends of MS in the city of Catania over the last 5 decades (1970\u20132019). Methods: Incident cases of MS in residents in the city of Catania at disease onset were identified using the registries of the main MS centers. The annualized incidence risk was based on the year of clinical onset. Results: From 1970 to 2019, a total of 754 incident cases were identified. The annualized incidence risk increased sharply from 0.7\/100,000 in 1970\u20131974 to 9.2\/100,000 in 2015\u20132019. The female-to-male ratio increased from 0.83 (95% CI: 0.26\u20132.62) in 1970\u20131974 to 2.14 (95% CI: 1.47\u20133.17) in 2015\u20132019. The mean age at onset was 29.1 \u00b1 8.2 years in 1970\u20131974, reaching a mean of 37.1 \u00b1 11.3 years in 2015\u20132019. Conclusion: Incidence of MS has been steadily increasing in the city of Catania, reaching a peak in 2015\u20132019 confirming Catania as one of the highest incidence areas in Italy. Additionally, we observed an increasing age at onset for both sexes, which may be attributable to improved diagnosis of late-onset MS cases.<\/jats:p>","DOI":"10.1159\/ned\/adwag012","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:31:17Z","timestamp":1786707077000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of Multiple Sclerosis in the City of Catania: A 50-Year Observational Population-Based Study"],"prefix":"10.1159","author":[{"given":"Alessandra","family":"Nicoletti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8647-8851","authenticated-orcid":false,"given":"Calogero Edoardo","family":"Cicero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara 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