{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:57:20Z","timestamp":1791190640807,"version":"4.1.0"},"reference-count":17,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"abstract":"<jats:p>Introduction: Survival from cardiac arrest is directly and consistently linked to the quality of chest compressions (CC). Although compressor fatigue is well established, neonatal resuscitation guidelines (NRP) do not offer specific recommendations on rotation intervals beyond suggesting provider changes every 2\u20135 min. By comparison, Pediatric Advanced Life Support recommends a strict 2-min rotation to prevent fatigue and maintain high-quality CC. Methods: Prospective observational data from resuscitation of asphyxiated cardiac-arrested neonatal lambs to evaluate changes in chest compression rate, blood pressure, carotid blood flow with duration of CC by a single compressor. Forty-one near-term lambs were asphyxiated by umbilical cord occlusion until asystole resuscitated using NRP\u2019s synchronized three CC to one ventilation algorithm. Results: The error rate of providing &gt;3 or &lt;3 CC between ventilations was &lt;1%. The CC rate and the percentage of lambs that received NRP\u2019s goal CC rate of 90\/min decreased over time (p &lt; 0.005). After 91\u2013120 s of chest compressions, CC rate decreased by 4% [3%,6%], carotid flow decreased by 21% [7%,35%], systolic blood pressure decreased by 3.1 [1.1,5.0] mm Hg or 10% [3%,16%], and mean blood pressure decreased by 1.0 [0.3,1.7] or 7% [2%,12%] at the 95% confidence interval compared to baseline CC during the first 30 s (p &lt; 0.05). Conclusions: Extended duration of CC beyond 2 min is associated with a decrease in carotid blood flow, CC rate, systolic and mean arterial blood pressure. To maintain optimal cerebral perfusion in an ovine model of cardiac arrest, rotating compressors every 2 min may minimize fatigue-induced decrease in CC efficacy.<\/jats:p>","DOI":"10.1159\/neo\/adsag004","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:02:07Z","timestamp":1786021327000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Hemodynamic Data in an Ovine Model to Estimate Optimal Time for Compressor Change during Neonatal Resuscitation"],"prefix":"10.1159","author":[{"given":"Evan M.","family":"Giusto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Vali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Sankaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Riley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Lesneski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Valdez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Hardie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria L.","family":"Hammitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Bowditch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessa Rose Amora","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Maher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyan","family":"Lakshminrusimha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-46862-x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.066882"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0300-9572(02)00168-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1892"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001369"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2022-324529"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001248"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-01306-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002289"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2013.10.011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.04.009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.165"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1620231"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2018.07.015"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1965.23.2.0191"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5479209"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0265072"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/neo\/adsag004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:47:54Z","timestamp":1791190074000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/neo\/adsag004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":17,"URL":"https:\/\/doi.org\/10.1159\/neo\/adsag004","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.33195942","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]}}}