{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:39:39Z","timestamp":1792687179291,"version":"4.5.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"abstract":"<jats:p>Introduction: Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening condition requiring intensive cardiopulmonary support. The optimal systemic blood pressure target in this population remains unknown. We evaluated the association between clinician-selected mean arterial pressure (MAP) targets and in-hospital outcomes in infants with PPHN. Methods: We conducted a retrospective cohort study of infants \u226535 weeks\u2019 gestation with PPHN treated with inhaled nitric oxide (iNO) who had a clinician-documented MAP target within the first 48 hours of age. Infants were classified as having a MAP target &lt;50 mmHg or \u226550 mmHg. The primary outcome was the composite of extracorporeal membrane oxygenation (ECMO) and\/or death. Results: Among 109 infants, 82 (75%) were in the MAP target group &lt; 50 mmHg and 27 (25%) were in the \u2265 50 mmHg MAP target group. Compared with a &lt; 50 mmHg MAP target, a \u2265 50 mmHg MAP target was associated with higher rates of ECMO cannulation (33% vs 11%, p=0.01) and ECMO\/death (48% vs 20%, p&lt;0.01). Use of epinephrine and hydrocortisone, use of more than two vasoactive agents, and the vasoactive-inotropic score were also higher in the \u2265 50 mmHg MAP target group. After adjustment for HIE, pneumothorax, and initial oxygenation index, the \u2265 50 mmHg MAP target remained associated with ECMO cannulation (aOR 4.8; 95% CI 1.6, 15.0) and ECMO\/death (aOR 5.9; 95% CI 2.0, 17.3). Conclusion: Among neonates treated with iNO for PPHN, clinician-selected MAP targets \u2265 50 mmHg were independently associated with ECMO cannulation and ECMO\/death. Randomized trials are needed to define safe MAP targets in PPHN.<\/jats:p>","DOI":"10.1159\/neo\/adsag033","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:49:42Z","timestamp":1792583382000},"source":"Crossref","is-referenced-by-count":0,"title":["Systemic Arterial Blood Pressure Targets and Extracorporeal Membrane Oxygenation or Death in Persistent Pulmonary Hypertension of Newborns: A Cohort Analysis"],"prefix":"10.1159","author":[{"given":"Marina Santos","family":"Oren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyan","family":"Lakshminrusimha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Bautista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kikelomo","family":"Babata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Steven","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Kapadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Makkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,10,21]]},"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/neo\/adsag033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:01:22Z","timestamp":1792684882000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/neo\/adsag033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/neo\/adsag033","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.34714473","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]}}}