{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:44:12Z","timestamp":1792514652550,"version":"4.5.0"},"reference-count":19,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"abstract":"<jats:p>Introduction: KRASG12C inhibitors such as sotorasib have expanded precision-oncology options for non-small cell lung cancer (NSCLC). However, central nervous system (CNS) disease control remains a major clinical challenge. Case Presentation: We report the case of a female patient with extensively pretreated KRASG12C-mutated lung adenocarcinoma and metachronous progressive brain metastases. Initially, peripheral and cerebral lesions responded to once daily sotorasib 960 mg (standard dose). Following cerebral progression, tolerance-adapted escalation to 1,920 mg achieved renewed intracranial disease control. Conclusion: In conclusion, this case illustrates that tolerance-adapted dose escalation may offer a meaningful therapeutic option for selected patients experiencing CNS progression under standard dosing.<\/jats:p>","DOI":"10.1159\/ort\/aecag005","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:01:39Z","timestamp":1792339299000},"page":"1-1","source":"Crossref","is-referenced-by-count":0,"title":["Dose-Dependent Intracranial Response to Sotorasib in KRAS\n                    <sup>G12C<\/sup>\n                    -Mutated Lung Cancer Brain Metastases: A Case Report"],"prefix":"10.1159","author":[{"given":"Niklas","family":"Hoersting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Hense","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2166-3394","authenticated-orcid":false,"given":"Martin","family":"Schuler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nika","family":"Guberina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Guberina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Wiesweg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14215430"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01574-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01839-y"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00221-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2103695"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/PO.22.00621"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2022.100428"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02524"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2025.108683"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32517-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0205-x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-40235-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3187"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1200\/PO.23.00030"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105074"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106137"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-017-0411-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00046"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-0383"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/ort\/aecag005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:01:56Z","timestamp":1792512116000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/ort\/aecag005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,17]]},"references-count":19,"URL":"https:\/\/doi.org\/10.1159\/ort\/aecag005","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.33327312","asserted-by":"subject"}]},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"value":"2296-5270","type":"print"},{"value":"2296-5262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,17]]}}}