{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:12:12Z","timestamp":1745554332574,"version":"3.40.4"},"reference-count":5,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathobiology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To investigate the effects of Z-100, an arabinomannan extracted from &lt;i&gt;Mycobacterium tuberculosis&lt;\/i&gt;, on the LP-BM5 murine leukemia virus (LP-BM5 MuLV) infection in mice. &lt;i&gt;Methods:&lt;\/i&gt; C57BL\/6 mice infected intraperitoneally with 4.5 \u00d7 10&lt;sup&gt;2&lt;\/sup&gt; PFU\/mouse of LP-BM5 MuLV (MAIDS mice) were treated intraperitoneally with a 10-mg\/kg dose of Z-100 every other day beginning 1 day after the viral infection. MAIDS mice treated with Z-100 were compared with control mice (MAIDS mice treated with saline) for their survival and splenomegaly after LP-BM5 infection. Cytokine-producing profiles of splenic T cells from these two groups of mice were also compared. &lt;i&gt;Results:&lt;\/i&gt; When MAIDS mice treated with Z-100 were compared with those of control mice, a decrease in splenomegaly and lymphadenopathy was observed. Splenomegaly was markedly enhanced in MAIDS mice treated intraperitoneally with IL-4 or IL-10. When MAIDS mice were treated with Z-100, their survival rates were significantly increased compared to those of controls. Splenic T cells from control mice produced type-2 cytokines (IL-4 and IL-10). However, a decreased production of type-2 cytokines by splenic T cells from MAIDS mice treated with Z-100 was demonstrated. &lt;i&gt;Conclusion:&lt;\/i&gt; Z-100 could decrease the severity of the LP-BM5 MuLV infection through the regulation of MAIDS-associated type-2 T-cell responses.<\/jats:p>","DOI":"10.1159\/000048762","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T13:07:10Z","timestamp":1050412030000},"page":"96-103","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Z-100, a &lt;i&gt;Mycobacterium-tuberculosis&lt;\/i&gt;-Derived Arabinomannan, on the LP-BM5 Murine Leukemia Virus Infection in Mice"],"prefix":"10.1159","volume":"69","author":[{"given":"Hidetaka","family":"Sasaki","sequence":"first","affiliation":[]},{"given":"Makiko","family":"Kobayashi","sequence":"additional","affiliation":[]},{"given":"Richard B.","family":"Pollard","sequence":"additional","affiliation":[]},{"given":"Fujio","family":"Suzuki","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2001,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/338505a0"},{"key":"ref2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2000.4854"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(94)90223-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(88)90116-2"}],"container-title":["Pathobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/48762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/48762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:06:48Z","timestamp":1745467608000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000048762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2001,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000048762","archive":["Portico"],"relation":{},"ISSN":["1015-2008","1423-0291"],"issn-type":[{"type":"print","value":"1015-2008"},{"type":"electronic","value":"1423-0291"}],"subject":[],"published":{"date-parts":[[2001]]}}}