{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T08:53:03Z","timestamp":1760345583530,"version":"3.40.4"},"reference-count":5,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Graft-versus-host disease (GvHD) remains the major toxicity of allogeneic bone marrow transplantation (BMT). In the acute form of the disease, the differential diagnosis includes viral rash and drug eruptions. &lt;i&gt;Methods:&lt;\/i&gt; We report two patients with chronic myeloid leukemia submitted to allogeneic BMT who developed a severe form of acute cutaneous GvHD, with clinical and histological pictures mimicking toxic epidermal necrolysis (TEN). &lt;i&gt;Results:&lt;\/i&gt; We found a predominance of peripheral CD8+ T lymphocytes and, at the same time, studying the cellular profile of the blister fluid, just in the beginning of blister eruption, we also found a high proportion of CD8+ T lymphocytes, mainly CD8+CD57\u2013. &lt;i&gt;Conclusion:&lt;\/i&gt; These data are in agreement with previous reports of the presence of CD8+ T cells in the blister fluid of patients with TEN, further emphasizing similar immunoinflammatory pathways in both diseases.<\/jats:p>","DOI":"10.1159\/000051751","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"212-216","source":"Crossref","is-referenced-by-count":25,"title":["CD8+ Lymphocytes in the Blister Fluid of Severe Acute Cutaneous Graft-versus-Host Disease: Further Similarities with Toxic Epidermal Necrolysis"],"prefix":"10.1159","volume":"203","author":[{"given":"O.","family":"Correia","sequence":"first","affiliation":[]},{"given":"L.","family":"Delgado","sequence":"additional","affiliation":[]},{"given":"I.L.","family":"Barbosa","sequence":"additional","affiliation":[]},{"given":"J.C.","family":"Domingues","sequence":"additional","affiliation":[]},{"given":"R.","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"C.P.","family":"Vaz","sequence":"additional","affiliation":[]},{"given":"P.","family":"Pimentel","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2001,11,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.5.602"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5388.490"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.129.4.466"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199709000-00002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.127.6.851"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/51751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/51751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:09:15Z","timestamp":1745467755000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000051751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000051751","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2001]]}}}