{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:04:57Z","timestamp":1770501897507,"version":"3.49.0"},"reference-count":4,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>In view of the known anti-inflammatory activities of interleukin (IL) 10, we investigated whether the administration of recombinant murine IL-10 prolonged corneal graft survival. A major histocompatibility complex mismatched rat model with AO rats as recipients of PVG donor corneas was used. A total of 39 corneal allografts was included in this study and divided into 7 groups for different treatments. Group\u00a0I (n = 6), II (n = 8), III (n = 6) and IV (n = 7) were injected subconjunctivally with saline (control), 0.5\u00a0ng, 5\u00a0ng or 50\u00a0ng of IL-10, respectively, on the day of transplantation and then on postoperative days (POD) 2, 4, 6, 8 and 10. Group\u00a0V (n = 4) and group\u00a0VI (n = 4) were injected intraperitoneally with saline (control) or 1\u00a0\u00b5g of IL-10, respectively, on the day before surgery, the day of grafting and then on POD 2, 4 and 6. Finally, group VII (n = 4) was injected with both subconjuctival 5\u00a0ng of IL-10 and intraperitoneal 1\u00a0\u00b5g of IL-10 on the same days as the previous groups. The median days for corneal rejection in the various groups were: group\u00a0I, 11.3 \u00b1 0.9; group\u00a0II, 11.5 \u00b1 0.9; group\u00a0III, 11.6 \u00b1 0.8, and group\u00a0IV, 10 \u00b1 1.0. Statistical analysis revealed a trend towards rejection (p = 0.08) in group\u00a0IV (compared to group\u00a0I). In groups\u00a0V and VI, corneal rejection was evident on day 12 and in group\u00a0VII the median time for rejection was 10.5 \u00b1 0.8 days. These results indicate that IL-10 treatment does not prolong corneal allograft survival and may even accelerate rejection.<\/jats:p>","DOI":"10.1159\/000055550","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"297-303","source":"Crossref","is-referenced-by-count":10,"title":["Interleukin 10 Treatment Does Not Prolong Experimental Corneal Allograft Survival"],"prefix":"10.1159","volume":"31","author":[{"given":"Paulo F.","family":"Torres","sequence":"first","affiliation":[]},{"given":"Alex F.","family":"de Vos","sequence":"additional","affiliation":[]},{"given":"Berta","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Aize","family":"Kijlstra","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[1999,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.4.915"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.5.1209"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.6.1625"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0966-3274(93)90033-5"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/55550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/55550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:39:18Z","timestamp":1745469558000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000055550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":4,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1999,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000055550","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999]]}}}