{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:09:17Z","timestamp":1772791757910,"version":"3.50.1"},"reference-count":7,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Toxic epidermal necrolysis (TEN) is a rare, drug-induced disease characterized by epidermal detachment and mucosal involvement. After an acute period, potentially disabling cutaneous and ocular sequels may appear. Although long-term complications are not rare, only few outcome studies are published. &lt;i&gt;Objective:&lt;\/i&gt; To evaluate the incidence of dermatological and ophthalmological sequels following TEN, to describe its clinical aspects and correlation with acute involvement. &lt;i&gt;Patients and Methods:&lt;\/i&gt; Eight patients surviving to TEN were submitted to dermatological and ophthalmological observation ranging from 0.5 to 8 years after hospitalization. Cutaneous and ocular involvement, during the acute phase, was retrospectively analysed. &lt;i&gt;Results:&lt;\/i&gt; Dermatological sequels were observed in 6 patients (75%) corresponding to those with more extensive skin involvement in the acute phase. The most frequent complications were cutaneous dyschromia (62.5%) and nail dystrophies (37.5%). Six patients (75%) had ocular complications with tarsal conjunctiva keratinization in 5 (62.5%) and keratoconjunctivitis sicca in 4 of them (50%). Trichiasis, corneal neovascularization and symblepharon were observed in 1 case. There was no correlation between the severity of acute ocular involvement and long-term complications. &lt;i&gt;Conclusion:&lt;\/i&gt; Following TEN, most patients have dermatological and ophthalmological sequels that persist for several years.<\/jats:p>","DOI":"10.1159\/000070938","type":"journal-article","created":{"date-parts":[[2003,7,11]],"date-time":"2003-07-11T08:22:02Z","timestamp":1057911722000},"page":"33-36","source":"Crossref","is-referenced-by-count":72,"title":["Dermatological and Ophthalmological Sequels in Toxic Epidermal Necrolysis"],"prefix":"10.1159","volume":"207","author":[{"given":"S.","family":"Magina","sequence":"first","affiliation":[]},{"given":"C.","family":"Lisboa","sequence":"additional","affiliation":[]},{"given":"V.","family":"Leal","sequence":"additional","affiliation":[]},{"given":"J.","family":"Palmares","sequence":"additional","affiliation":[]},{"given":"J.","family":"Mesquita-Guimar\u00e3es","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2003,7,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.129.1.92"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.5.602"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000051751"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.129.4.466"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5388.490"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000051702"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.123.9.1160"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/70938","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/70938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:25:58Z","timestamp":1745465158000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000070938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000070938","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}