{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:12:59Z","timestamp":1761016379102,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T00:00:00Z","timestamp":1104364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T00:00:00Z","timestamp":1104364800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Exp Nephrol"],"abstract":"<i>Background:<\/i> Renal dopamine exerts natriuretic and diuretic effects by activating D<sub>1<\/sub>-like receptors. Uninephrectomy results in increased renal dopaminergic activity and dopamine-sensitive enhanced natriuresis. <i>Methods:<\/i> The present study evaluated renal adaptations in sodium handling and the role of dopamine in rats submitted to \u00be nephrectomy: right nephrectomy and excision of both poles of the left kidney (\u00benx rats). <i>Results:<\/i> Two weeks after surgery the absolute urinary levels of dopamine were markedly reduced in \u00benx rats whereas the urinary dopamine excretion per % of residual nephrons was significantly increased in the remnant kidney of \u00benx rats. The V<sub>max<\/sub> values for renal aromatic <i>L<\/i>-amino acid decarboxylase, the enzyme responsible for the synthesis of renal dopamine, were decreased in \u00benx rats. Renal catechol-<i>O<\/i>-methyltransferase activity, the enzyme responsible for the methylation of dopamine, was increased in \u00benx rats whereas the renal activities of monoamine oxidases A and B did not differ between \u00benx and Sham animals. Volume expansion (5% body weight) resulted in similar natriuretic responses in \u00benx and Sham rats. During D<sub>1<\/sub> antagonist administration (Sch-23390, 30 \u00b5g\u00b7h<sup>\u20131<\/sup>\u00b7kg<sup>\u20131<\/sup>) the natriuretic response to volume expansion was reduced in \u00benx rats more pronouncedly than in Sham animals. <i>Conclusion:<\/i> The decrease in absolute renal dopamine output in \u00benx rats is related with reduced renal synthesis and enhanced <i>O<\/i>-methylation of the amine. However, this is accompanied in \u00benx rats by increased renal dopamine excretion per residual nephrons and dopamine-sensitive enhanced natriuresis.<\/jats:p>","DOI":"10.1159\/000082868","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T10:00:23Z","timestamp":1104400823000},"page":"e46-e55","source":"Crossref","is-referenced-by-count":19,"title":["Renal Dopaminergic System Activity in the Rat Remnant Kidney"],"prefix":"10.1159","volume":"99","author":[{"given":"B.","family":"Sampaio-Maia","sequence":"first","affiliation":[]},{"given":"P.","family":"Serr\u00e3o","sequence":"additional","affiliation":[]},{"given":"J.T.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[]},{"given":"M.A.","family":"Vieira-Coelho","sequence":"additional","affiliation":[]},{"given":"M.","family":"Pestana","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2004,12,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1474-8673.1990.tb00224.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1997.390"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1993.144"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1974.72"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1748-1716.1992.tb09376.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2899%2901063-X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1986.45"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1991.52"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.physiol.62.1.621"}],"container-title":["Nephron Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/82868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:27:21Z","timestamp":1745465241000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000082868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,30]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000082868","archive":["Portico"],"relation":{},"ISSN":["1660-2129"],"issn-type":[{"type":"electronic","value":"1660-2129"}],"subject":[],"published":{"date-parts":[[2004,12,30]]}}}