{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:10:50Z","timestamp":1745554250792,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2005]]},"abstract":"<i>Background:<\/i> S-100B and tau protein have a high differential diagnostic potential for the diagnosis of Creutzfeldt-Jakob disease (CJD). So far there has been only limited information available about the dynamics of these parameters in the cerebrospinal fluid (CSF). However, there is a special interest in finding biochemical markers to monitor disease progression for differential diagnosis and treatment. <i>Patients and Methods:<\/i> We analyzed CSF of 45 patients with CJD and of 45 patients with other neurological diseases for tau protein and S-100B in a follow-up setting. All diagnoses of CJD were later neuropathologically verified. A ratio between tau protein differences and the time between lumbar puncture was calculated. The same was done for S-100B. <i>Results:<\/i> Tau protein levels of 34 cases were above the cut-off level for CJD (>1,300 pg\/ml) in the first CSF sample. In 7 of 11 patients with lower tau levels in the first CSF sample, tau levels rose. The above-mentioned ratio was significantly higher in the CJD group than in the group with other neurological diseases. Similar results were obtained for S-100B. <i>Conclusion:<\/i> We conclude that follow-up investigations and calculation of ratios is a useful tool in the differential diagnosis of CJD. Variations in this pattern were observed in single cases.<\/jats:p>","DOI":"10.1159\/000084708","type":"journal-article","created":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T08:14:07Z","timestamp":1112343247000},"page":"376-382","source":"Crossref","is-referenced-by-count":10,"title":["Follow-Up Investigations of Tau Protein and S-100B Levels in Cerebrospinal Fluid of Patients with Creutzfeldt-Jakob Disease"],"prefix":"10.1159","volume":"19","author":[{"given":"Lukas","family":"Cepek","sequence":"first","affiliation":[]},{"given":"Petra","family":"Steinacker","sequence":"additional","affiliation":[]},{"given":"Brit","family":"Mollenhauer","sequence":"additional","affiliation":[]},{"given":"Birgitt","family":"Wiese","sequence":"additional","affiliation":[]},{"given":"Barbara","family":"Ciesielczyk","sequence":"additional","affiliation":[]},{"given":"Mirko","family":"Bibl","sequence":"additional","affiliation":[]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[]},{"given":"Inga","family":"Zerr","sequence":"additional","affiliation":[]},{"given":"Walter","family":"Schulz-Schaeffer","sequence":"additional","affiliation":[]},{"given":"Hans A.","family":"Kretzschmar","sequence":"additional","affiliation":[]},{"given":"Sigrid","family":"Poser","sequence":"additional","affiliation":[]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2005,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2897%2900215-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.71.3.401"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.74.9.1210"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000017095"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004150050145"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199609263351303"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F1531-8249%28200009%2948%3A3%3C395%3A%3AAID-ANA18%3E3.0.CO%3B2-A"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410430109"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.70.6.744"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.60.6.803"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.60.6.813"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.97.10.5468"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2912075-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.55.7.937"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2803%2900002-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1258%2F000456303321016141"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410050212"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410390613"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2F0009-8981%2892%2990103-W"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.73.1.79"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.10661"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/84708","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/84708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:45:00Z","timestamp":1745466300000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000084708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"references-count":21,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000084708","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2005]]}}}