{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:58:02Z","timestamp":1745470682915,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T00:00:00Z","timestamp":1144713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T00:00:00Z","timestamp":1144713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Physiol"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; The present study examined the effects of chronic selective or combined inhibition of type A monoamine oxidase (MAO) and catechol-&lt;i&gt;O&lt;\/i&gt;-methyltransferase (COMT) on daily urinary excretion of dopamine and metabolites and on natriuresis and phosphaturia in 3\/4 nephrectomized (3\/4nx) and Sham rats. &lt;i&gt;Methods:&lt;\/i&gt; The 3\/4nx and Sham rats were placed in metabolic cages and received the MAO-A-selective inhibitor Ro-411049 (7.5 mg\u00b7kg&lt;sup&gt;\u20131&lt;\/sup&gt; bid) and\/or the COMT-selective inhibitor BIA 3-202 (30 mg\u00b7kg&lt;sup&gt;\u20131&lt;\/sup&gt; bid) orally for 3 days during high sodium diet. &lt;i&gt;Results:&lt;\/i&gt; Selective COMT inhibition increased the urinary excretion of the deaminated metabolite (3,4-dihydroxyphenylacetic acid, DOPAC) and decreased the urinary excretion of the methylated (3-methoxytyramine, 3-MT) and deaminated plus methylated metabolite (homovanillic acid, HVA) in both groups. Selective MAO-A inhibition increased the urinary excretion of 3-MT and reduced the urinary excretion of both DOPAC and HVA in either 3\/4nx or Sham rats. Combined inhibition of MAO-A and COMT did not significantly change the urinary excretion of DOPAC and markedly decreased the urinary excretion of 3-MT and HVA in both groups. Selective or combined inhibition of MAO-A and COMT did not alter the daily urinary excretion of dopamine, sodium or phosphate in either 3\/4nx or Sham rats. &lt;i&gt;Conclusions:&lt;\/i&gt; Chronic selective or combined inhibition of MAO-A and COMT is not of major importance in regulating the dopamine-dependent natriuresis and phosphaturia in either 3\/4nx or Sham rats.<\/jats:p>","DOI":"10.1159\/000090219","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T07:28:44Z","timestamp":1212132524000},"page":"p14-p24","source":"Crossref","is-referenced-by-count":11,"title":["Role of Chronic Inhibition of Dopamine-Metabolizing Enzymes in the Regulation of Renal Sodium and Phosphate Excretion in the Rat Remnant Kidney"],"prefix":"10.1159","volume":"103","author":[{"given":"Benedita","family":"Sampaio-Maia","sequence":"first","affiliation":[]},{"given":"M\u00f3nica","family":"Moreira-Rodrigues","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Pestana","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2006,4,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1517%2F13543784.11.5.631"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.physiol.62.1.621"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000025844"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000076022"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000082868"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1993.144"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1997.390"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2001.0590051683.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-201X.1998.00319.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000020619"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1021%2Fjm0109964"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1991.30"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1748-1716.1992.tb09376.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.1985.tb12884.x"}],"container-title":["Nephron Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/90219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:41:58Z","timestamp":1745462518000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000090219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,11]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000090219","archive":["Portico"],"relation":{},"ISSN":["1660-2137"],"issn-type":[{"type":"electronic","value":"1660-2137"}],"subject":[],"published":{"date-parts":[[2006,4,11]]}}}