{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:00:53Z","timestamp":1773154853188,"version":"3.50.1"},"reference-count":40,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>Measurement of \u03c4-protein and \u03b2-amyloid&lt;sub&gt;1\u201342 &lt;\/sub&gt;(A\u03b242) in cerebrospinal fluid (CSF) has gained increasing acceptance in the differential diagnosis of Alzheimer\u2019s disease. We investigated CSF \u03c4-protein and A\u03b242 concentrations in 73 patients with advanced idiopathic Parkinson\u2019s disease with dementia (PDD) and 23 patients with idiopathic Parkinson\u2019s disease without dementia (PD) and in a comparison group of 41 non-demented neurological patients (CG) using commercially available enzyme-linked-immunoabsorbant-assay (ELISA). \u03c4-Protein levels were statistically significantly higher and A\u03b242 lower in the PDD patients compared to PD patients and the CG. This observation was most marked (p &lt; 0.05) in a subgroup of patients with PDD carrying the apolipoprotein genotype &amp;#917;3\/&amp;#917;3. The distribution of the apolipoprotein genotypes in PDD and PD patients was similar to that of the CG. Although a significant difference in \u03c4-protein values was observed between PDD and CG, no diagnostic cut-off value was established. These findings suggest that such protein CSF changes may help to support the clinical diagnosis of cognitive decline in PD and that there may be apolipoprotein-E-isoform-specific differences in CSF protein regulation in advanced PDD.<\/jats:p>","DOI":"10.1159\/000094871","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T14:11:05Z","timestamp":1155132665000},"page":"200-208","source":"Crossref","is-referenced-by-count":109,"title":["Beta-Amlyoid 1\u201342 and Tau-Protein in Cerebrospinal Fluid of Patients with Parkinson\u2019s Disease Dementia"],"prefix":"10.1159","volume":"22","author":[{"given":"Brit","family":"Mollenhauer","sequence":"first","affiliation":[]},{"given":"Claudia","family":"Trenkwalder","sequence":"additional","affiliation":[]},{"given":"Nicolas","family":"von 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