{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T10:46:51Z","timestamp":1761821211529,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T00:00:00Z","timestamp":1165968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T00:00:00Z","timestamp":1165968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Genomics"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; It was the aim of this study to determine the depression scores of Machado-Joseph disease (MJD) patients, their spouses, and individuals at 50% risk for MJD, and second, to verify the existence of a correlation between depressive symptoms and the degree of motor incapacitation. &lt;i&gt;Subjects and Methods:&lt;\/i&gt; Two hundred and forty-six individuals aged \u226718 years were studied: 79 MJD patients (group 1), 43 spouses of MJD patients (group 2), 80 individuals at risk for MJD (group 3), and a control group (group 4) composed of 44 patients with multiple sclerosis (MS). The following two tools were applied: the Beck Depression Inventory and the Barthel index of physical incapacitation, both in an adapted Brazilian Portuguese version. &lt;i&gt;Results:&lt;\/i&gt; Moderate to severe depressive scores were found in 33.5% of patients in the MJD families, in 16.3% of the spouses, and in 6.3% of the individuals at risk. This linear reduction between MJD family members was statistically significant (p &lt; 0.0001, ANOVA). Depressive scores were also associated with age and the female sex. A direct correlation between Beck Depression Inventory scores and motor incapacitation was found in MJD patients (r = 0.507, Pearson correlation, p &lt; 0.0001). Although the depressive symptoms in the control group with MS were higher than those found in MJD patients (59% of MS patients showed moderate to severe scores), depression did not correlate with physical incapacitation, age, or education attainment in the MS group. &lt;i&gt;Conclusions:&lt;\/i&gt; Depressive symptoms are rather common in MJD patients and in their spouses (caregivers). In this condition, depression seemed to be more reactive than primarily related to the disease process itself.<\/jats:p>","DOI":"10.1159\/000096276","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T15:03:55Z","timestamp":1166195035000},"page":"19-26","source":"Crossref","is-referenced-by-count":34,"title":["Depressive Symptoms in Machado-Joseph Disease (SCA3) Patients and Their Relatives"],"prefix":"10.1159","volume":"10","author":[{"given":"C.R.","family":"Cecchin","sequence":"first","affiliation":[]},{"given":"A.P.","family":"Pires","sequence":"additional","affiliation":[]},{"given":"C.R.","family":"Rieder","sequence":"additional","affiliation":[]},{"given":"T.L.","family":"Monte","sequence":"additional","affiliation":[]},{"given":"I.","family":"Silveira","sequence":"additional","affiliation":[]},{"given":"T.","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"M.L.","family":"Saraiva-Pereira","sequence":"additional","affiliation":[]},{"given":"J.","family":"Sequeiros","sequence":"additional","affiliation":[]},{"given":"L.B.","family":"Jardim","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2006,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-510X%2872%2990137-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1194-221"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F9.6.909"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.58.11.1821"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0404.2001.00020.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410130302"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1037%2F0278-6133.16.1.20"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ejhg.5200532"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.38.12.852"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10897-005-4063-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02895167"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089%2F109065704323015987"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000082262"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410400311"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.10033"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.159.8.1306"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.59.11.1804"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0277-9536%2890%2990211-A"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-2388%28200006%2918%3A4%3C333%3A%3AAID-SSU8%3E3.0.CO%3B2-4"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1089%2Fgte.2004.8.421"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F109.4.585"}],"container-title":["Public Health Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/96276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:51:07Z","timestamp":1745463067000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000096276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,13]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000096276","archive":["Portico"],"relation":{},"ISSN":["1662-4246","1662-8063"],"issn-type":[{"type":"print","value":"1662-4246"},{"type":"electronic","value":"1662-8063"}],"subject":[],"published":{"date-parts":[[2006,12,13]]}}}