{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T16:47:31Z","timestamp":1767372451970,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Recent studies have shown high rates of morbimortality associated with hyperkalemia in congestive heart failure (CHF) patients treated with angiotensin-converting enzyme inhibitors (ACEI) plus spironolactone and the best predictor of this electrolytic disorder was a decrease in renal function. We aim to identify the incidence and predictors of acute renal failure (ARF) related to treatment with ACEI associated or not with spironolactone. &lt;i&gt;Methods:&lt;\/i&gt; We conducted a cohort study and followed 114 consecutive cases of CHF patients treated with ACEI at admission to a University Hospital. We performed measurements of serum creatinine and potassium levels three times a week, and systolic and diastolic blood pressures every 8 h, daily. &lt;i&gt;Results:&lt;\/i&gt; Among 114 patients, 25% developed ARF, 15% hyperkalemia and 3% severe hyperkalemia. Predictors of ARF were a decrease in average blood pressure 25 mm Hg (OR 18.2; 95% CI: 6.2, 53.5); class IV CHF (OR 4.7; 95% CI: 1.7, 12.7), diabetes (OR 2.6; 95% CI: 1.1, 6.4) and hypertension (OR 3.0; 95% CI: 1.2, 7.4). &lt;i&gt;Conclusions:&lt;\/i&gt; ARF and hyperkalemia are common complications in CHF patients after treatment with ACEI. Diabetic, hypertensive and class IV CHF patients who experienced a decrease in average blood pressure 25 mm Hg were more susceptible to ARF.<\/jats:p>","DOI":"10.1159\/000097658","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T12:39:49Z","timestamp":1164976789000},"page":"c77-c83","source":"Crossref","is-referenced-by-count":13,"title":["Incidence and Predictors of Development of Acute Renal Failure Related to Treatment of Congestive Heart Failure with ACE Inhibitors"],"prefix":"10.1159","volume":"105","author":[{"given":"Constan\u00e7a S.","family":"Cruz","sequence":"first","affiliation":[]},{"given":"Luzia S.","family":"Cruz","sequence":"additional","affiliation":[]},{"given":"Giulliana R.","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Carlos A.","family":"Marc\u00edlio de Souza","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9149%2892%2991194-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1532-5415.2002.50321.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.327.7424.1141"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2802%2902694-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg295"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc4101.096153"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000143547.55093.17"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1157%2F13084633"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-8703%2899%2970009-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2003.07.031"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.105.580506"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1157%2F13084636"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/97658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:05:27Z","timestamp":1745463927000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000097658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,1]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000097658","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"type":"electronic","value":"1660-2110"}],"subject":[],"published":{"date-parts":[[2006,12,1]]}}}