{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:18:03Z","timestamp":1759483083201,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background\/Aim:<\/i> The determinants of baseline fast solute transport are still unclear. We prospectively investigated the relationship of peritoneal solute transport with markers of inflammation, angiogenesis, and membrane status, with a focus on fast transporters. <i>Methods:<\/i> Seventy-one incident peritoneal dialysis patients were assessed with baseline and annual peritoneal equilibration tests, using a 3.86% glucose dialysis solution. Residual renal function and markers of inflammation, including systemic and intraperitoneal interleukin-6 (IL-6), effluent cancer antigen 125 (CA-125), and vascular endothelial growth factor (VEGF) appearance rates (ARs), were investigated. The time course of the dialysate-to-plasma ratio of creatinine (D\/P creatinine ratio) and its relationship with the biomarkers were investigated by a mixed linear model. <i>Results:<\/i> Incident fast\/fast average transporters had a similar age, diabetes prevalence, and serum and effluent IL-6 levels, but significantly higher levels of CA-125 and VEGF ARs than the slow\/slow average group; the D\/P creatinine ratio was not correlated with systemic IL-6, but was correlated with effluent CA-125 AR (r = 0.45, p < 0.0001) and VEGF AR (r = 0.52, p < 0.0001). The D\/P creatinine ratio decreased with a U-shaped profile (p = 0.02). Intraperitoneal IL-6 was the significant and positive determinant of the time course of the D\/P creatinine ratio (p < 0.0001). Effluent CA-125 decreased with time on peritoneal dialysis (p = 0.013). <i>Conclusions:<\/i> Baseline peritoneal fast transport was not associated with systemic inflammation, but was related to peritoneal locally produced substances able to mediate transitory hyperpermeability. The D\/P creatinine ratio changed during the follow-up period with a U-shaped profile. This was associated with effluent IL-6 and partly with VEGF. CA-125 decreased throughout the follow-up period.<\/jats:p>","DOI":"10.1159\/000099332","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T10:24:44Z","timestamp":1170843884000},"page":"84-91","source":"Crossref","is-referenced-by-count":40,"title":["Evaluation of Peritoneal Transport and Membrane Status in Peritoneal Dialysis: Focus on Incident Fast Transporters"],"prefix":"10.1159","volume":"27","author":[{"given":"Anabela S.","family":"Rodrigues","sequence":"first","affiliation":[]},{"given":"Margarida","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Johanna C.","family":"Korevaar","sequence":"additional","affiliation":[]},{"given":"Sandra","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 C.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Antonio","family":"Cabrita","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Castro e Melo","sequence":"additional","affiliation":[]},{"given":"Raymond T.","family":"Krediet","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2007,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2003.11.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2001.21298"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F16.11.2240"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005050566"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2006030194"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F18.3.590"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfi245"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2800%2970304-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00353.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00143.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.66021.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfh793"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000085032"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1993.36"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F17.8.1480"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00357.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00604.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1997.125"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2005.08.011"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/99332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:39:43Z","timestamp":1745462383000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000099332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000099332","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"type":"print","value":"0250-8095"},{"type":"electronic","value":"1421-9670"}],"subject":[],"published":{"date-parts":[[2007]]}}}