{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:56:54Z","timestamp":1773860214684,"version":"3.50.1"},"reference-count":45,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To determine dysplasia and cancer in the 1991\u20132004 European Collaborative Inflammatory Bowel Disease (EC-IBD) Study Group cohort. &lt;i&gt;Patients and Methods:&lt;\/i&gt; A patient questionnaire and a physician per patient form were completed for each of the 1,141 inflammatory bowel disease patients (776 ulcerative colitis\/365 Crohn\u2019s disease) from 9 centers (7 countries) derived from the EC-IBD cohort. Rates of detection of intestinal cancer and dysplasia as well as extra-intestinal neoplasms were computed. &lt;i&gt;Results:&lt;\/i&gt; Patient follow-up time was 10.3 \u00b1 0.8 (range 9.4\u201311) years. The mean age of the whole group of IBD patients was 37.8 \u00b1 11.3 (range 16\u201376) years. Thirty-eight patients (3.3%; 26 with ulcerative colitis\/12 with Crohn\u2019s disease, 21 males\/17 females, aged 61.3 \u00b1 13.4, range 33\u201377 years), were diagnosed with 42 cancers. Cancers occurred 5.4 \u00b1 3.3 (range 0\u201311) years after inflammatory bowel disease diagnosis. Colorectal cancer was diagnosed in 8 (1 Crohn\u2019s disease and 7 ulcerative colitis patients \u2013 0.3 and 0.9% of the Crohn\u2019s disease and ulcerative colitis cohort, respectively) of 38 patients and 30 cancers were extra-intestinal. Four of 38 patients (10.5%) were diagnosed as having 2 cancers and they were younger compared to patients with one cancer (p = 0.0008). There was a trend for a higher prevalence of intestinal cancer in the northern centers (0.9%) compared to southern centers (0.3%, p = NS). Southern centers had more cases of extra-intestinal cancer compared to northern centers (2 vs. 3.8%, p = 0.08). Ten patients (0.9%; 8 with ulcerative colitis\/2 with Crohn\u2019s disease, 8 males, aged 62.3 \u00b1 14.1 years) had colorectal dysplasia. &lt;i&gt;Conclusions:&lt;\/i&gt; In the first decade of the EC-IBD Study Group cohort follow-up study, the prevalence of cancer was as expected with most patients having a single neoplasm and an extra-intestinal neoplasm. In northern centers there was a trend for more intestinal cancers, while in southern centers there was a trend for more extra-intestinal cancers compared to northern centers.<\/jats:p>","DOI":"10.1159\/000104731","type":"journal-article","created":{"date-parts":[[2007,6,27]],"date-time":"2007-06-27T06:31:53Z","timestamp":1182925913000},"page":"113-121","source":"Crossref","is-referenced-by-count":44,"title":["Dysplasia and Cancer in Inflammatory Bowel Disease 10 Years after Diagnosis: Results of a Population-Based European Collaborative Follow-Up 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