{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:50:14Z","timestamp":1760953814651,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2007]]},"abstract":"Invasive squamous cell carcinomas of the cervix arise from earlier, reversible precursor lesions called low- and high-grade squamous intraepithelial lesions (LSIL and HSIL, respectively). The aim of our study was to analyse the influence of the <i>CCR2-64I<\/i> polymorphism in the development of SIL due to its preponderant role in the cervical carcinogenesis and in the progression of these lesions to invasive cervical carcinoma. We conducted a case-control study, analyzing 565 Caucasian women from the north of Portugal. The <i>CCR2-64I<\/i> polymorphism was analysed through polymerase chain reaction followed by restriction fragment length polymorphism. The frequency of GG, GA and AA genotypes was 76.5, 23.5 and 0.0% respectively, in HSIL patients, and 87.8, 11.1 and 1.1% respectively, in the control group. The G allele frequency was 88.2% in the HSIL group and 93.4% in the control group. Regarding the A allele frequency, it was 11.8% in the HSIL group and 6.6% in the control group. Overall, the frequency of A carrier genotypes was higher in HSIL patients than in the control group (p = 0.013; OR = 2.21; 95%CI: 1.17\u20134.15), suggesting that <i>CCR2-64I<\/i> polymorphism might contribute to the establishment of HSIL, through the disruption of the naturally fragile immune response directed towards human papillomavirus infection.<\/jats:p>","DOI":"10.1159\/000106492","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T02:57:07Z","timestamp":1464058627000},"page":"208-212","source":"Crossref","is-referenced-by-count":13,"title":["The Influence of Chemokine Receptor CCR2 Genotypes in the Route to Cervical Carcinogenesis"],"prefix":"10.1159","volume":"64","author":[{"given":"Ana","family":"Coelho","sequence":"first","affiliation":[]},{"given":"Ana","family":"Matos","sequence":"additional","affiliation":[]},{"given":"Raquel","family":"Catarino","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Hugo","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Deolinda","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Medeiros","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2007,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00130404-200309000-00004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F01.cej.0000174780.44260.32"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F01.cej.0000178079.29533.1e"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cancergencyto.2003.08.020"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1067%2FS0002-9378%2803%2901079-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fpath.1866"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-04-1091"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrc700"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2004.10.019"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrc798"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2F84209"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0215%2819990702%2982%3A1%3C6%3A%3AAID-IJC2%3E3.0.CO%3B2-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fpath.1027"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS1359-6101%2801%2900033-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-5699%2892%2990008-U"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2004.11.028"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fnar%2F16.3.1215"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-1759%2801%2900349-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.11411"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.it.2004.09.015"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejca.2006.01.003"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2741%2Fwoodworth"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F00002030-200403260-00003"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:38:56Z","timestamp":1745462336000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000106492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000106492","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2007]]}}}