{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:54:46Z","timestamp":1763704486115,"version":"3.40.4"},"reference-count":32,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T00:00:00Z","timestamp":1198195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T00:00:00Z","timestamp":1198195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Objective:<\/i> In congenital diaphragmatic hernia (CDH) the severity of pulmonary hypertension (PH) is considered, by several authors, determinant of clinical outcome. Plasmatic N-terminal-pro-B type natriuretic peptide (NT-proBNP) might be useful in diagnosis and management of PH in newborns, although its interest in CDH infants remains to be defined. Early NT-proBNP levels were assessed in CDH infants and correlated with cardiovascular echocardiographic parameters. <i>Patients and Methods:<\/i> 28 newborns, CDH and age-matched controls were enrolled in a prospective study. Clinical condition, NT-proBNP plasmatic levels, echo parameters of PH and biventricular function were assessed at 24 h after delivery as well as survival outcome. <i>Results:<\/i> Estimated mean pulmonary pressure and NT-proBNP were significantly higher in CDH than control infants. NT-proBNP significantly correlated with estimated pulmonary artery pressure, right ventricular Tei index, and tricuspid E\/A ratio. Additionally, we found that CDH infants with NT-proBNP >11,500 pg\/ml experienced a worse prognosis. <i>Conclusions:<\/i> We demonstrated that PH is associated with NT-proBNP elevation and diastolic impairment in CDH infants. Early elevations in NT-proBNP levels seem to alert for a subset of CDH infants with worse prognosis.<\/jats:p>","DOI":"10.1159\/000112641","type":"journal-article","created":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T14:28:20Z","timestamp":1198247300000},"page":"22-30","source":"Crossref","is-referenced-by-count":32,"title":["N-Terminal-pro-B Type Natriuretic Peptide as a Useful Tool to Evaluate Pulmonary Hypertension and Cardiac Function in CDH Infants"],"prefix":"10.1159","volume":"94","author":[{"given":"Maria J.","family":"Baptista","sequence":"first","affiliation":[]},{"given":"Gustavo","family":"Rocha","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"Clemente","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds F.","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"Dick","family":"Tibboel","sequence":"additional","affiliation":[]},{"given":"Adelino F.","family":"Leite-Moreira","sequence":"additional","affiliation":[]},{"given":"Herc\u00edlia","family":"Guimar\u00e3es","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 C.","family":"Areias","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Correia-Pinto","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2007,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpedsurg.2003.11.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9440%2810%2965000-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpedsurg.2005.01.034"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000082595"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa035005"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000014050"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00383-006-1643-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000101343"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000097454"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1084-2756%2803%2900028-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000097125"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.2005.063784"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000144310.04433.BE"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1330207"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fheart.89.8.875"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.112.4.896"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080%2F08035250410025799"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1442-200X.2003.01716.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1080%2F08035250410022756"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080%2F080352501300049406"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-1837"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-0525"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-2780"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2885%2980477-0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9149%2887%2991189-1"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0894-7317%2897%2970090-7"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02078413"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159%2F000079424"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3468%2892%2990102-D"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1159%2F000100964"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijcard.2005.10.012"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007%2Fs003830000452"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/112641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:30:11Z","timestamp":1745461811000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000112641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,21]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000112641","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2007,12,21]]}}}