{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:12:58Z","timestamp":1762351978846,"version":"3.40.4"},"reference-count":35,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; The study evaluated the patterns of cerebrospinal fluid (CSF), amyloid-\u03b2 (A\u03b2) peptides, total tau and phospho-tau among Alzheimer\u2019s disease (AD) and vascular dementias (VAD). &lt;i&gt;Methods:&lt;\/i&gt; A\u03b2-SDS-PAGE immunoblot and commercially available ELISAs were applied to the CSF analysis of 52 patients with probable (n = 21) and possible (n = 16) VAD, AD with cerebrovascular disease (n = 15), 30 patients with probable AD and 30 nondemented disease controls. &lt;i&gt;Results:&lt;\/i&gt; AD and AD with cerebrovascular disease displayed a similar neurochemical phenotype in contrast to nondemented disease controls and probable VAD with regard to tau, p-tau, A\u03b21\u201340&lt;sup&gt;ox&lt;\/sup&gt; and A\u03b21\u201342%. Possible VAD displayed AD-like changes only for A\u03b21\u201340&lt;sup&gt;ox&lt;\/sup&gt; and A\u03b21\u201342%. &lt;i&gt;Conclusion:&lt;\/i&gt; CSF neurochemical phenotypes sufficiently discriminate probable AD and VAD from each other, but their diagnostic value is limited in case of no clear-cut clinical appearance, such as possible VAD. Conversely, CSF A\u03b2 peptides and p-tau levels may help estimate the involvement of AD-like pathophysiological pathways in VAD subgroups.<\/jats:p>","DOI":"10.1159\/000115975","type":"journal-article","created":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T11:16:35Z","timestamp":1202814995000},"page":"256-265","source":"Crossref","is-referenced-by-count":20,"title":["Cerebrospinal Fluid Neurochemical Phenotypes in Vascular Dementias: Original Data and 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