{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:18:01Z","timestamp":1757704681950,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1962,1,1]],"date-time":"1962-01-01T00:00:00Z","timestamp":-252460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1962,1,1]],"date-time":"1962-01-01T00:00:00Z","timestamp":-252460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[1962]]},"abstract":"<jats:p>Clinical and cytogenetic findings have been described in a family in which the mother had given birth in three successive pregnancies at the ages of 24, 28 and 30 years respectively to a child with the Klinefelter syndrome (44\/XXY), a normal male (44\/XY) and a daughter with the Langdon Down anomaly, with a translocation within the 21\u201322 group of chromosomes. No translocated chromosome was found in any other member of the family. All three children had different fathers.<\/jats:p>","DOI":"10.1159\/000129717","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T09:35:09Z","timestamp":1209548109000},"page":"75-89","source":"Crossref","is-referenced-by-count":22,"title":["Langdon Down Anomaly (Mongolism) with 21\/21 Translocation and Klinefelter\u2019s Syndrome in the same Sibship"],"prefix":"10.1159","volume":"1","author":[{"given":"K.","family":"Benirschke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Brownhill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hoefnagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.H.","family":"Allen Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,4,29]]},"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/129717","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/129717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:31:32Z","timestamp":1745458292000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000129717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1962]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000129717","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"type":"print","value":"1424-8581"},{"type":"electronic","value":"1424-859X"}],"subject":[],"published":{"date-parts":[[1962]]}}}