{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:56:32Z","timestamp":1777946192514,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T00:00:00Z","timestamp":1212105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T00:00:00Z","timestamp":1212105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"abstract":"<jats:p>Eight substituted pyrrole carboxylic acids were evaluated for their anti-inflammatory activity against carageenin-induced edema in rats. The protection afforded by seven of these compounds at a dose of 100 mg\/kg i.p. ranged from 11 to 42%. Indomethacin (10 mg\/kg i.p.), used as a reference drug, possessed 45% anti-inflammatory activity under similar experimental conditions. The ability of these compounds to exhibit in vitro antiproteolytic activity was reflected by their ability to inhibit trypsin-induced hydrolysis of bovine serum albumin. The inhibition of the activity of trypsin by these substituted pyrrole carboxylic acids (1 mM) ranged from 42 to 90% while such an inhibition with indomethacin (1 mM) was 95%. The in vitro membrane stabilizing property of these substituted pyrrole carboxylic acids was observed by their ability to provide protection against heat-induced dog erythrocyte hemolysis. The I&lt;sub&gt;50&lt;\/sub&gt; value of these compounds, representing the concentration required to inhibit one-half of heat-induced erythrocyte hemolysis, ranged from 0.29 to 6.0 mM. Such an inhibition was concentration-dependent and biphasic in nature. The I&lt;sub&gt;50&lt;\/sub&gt; value for indomethacin, showing greater antihemolytic activity was found to be 0.02 mM under similar experimental conditions. These results have provided some correlation of anti-inflammatory activity with antiproteolytic and membrane stabilizing properties for substituted pyrrole-3-carboxylic acids alone but not for pyrrole-2-carboxylic acids.<\/jats:p>","DOI":"10.1159\/000137562","type":"journal-article","created":{"date-parts":[[2008,6,2]],"date-time":"2008-06-02T07:26:06Z","timestamp":1212391566000},"page":"287-292","source":"Crossref","is-referenced-by-count":62,"title":["Anti-Inflammatory, Antiproteolytic, and Antihemolytic Properties of Pyrrole Carboxylic Acids"],"prefix":"10.1159","author":[{"given":"John S.","family":"Davis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surendra S.","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,5,30]]},"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000137562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:45:44Z","timestamp":1777736744000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000137562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000137562","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,30]]}}}