{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T07:18:32Z","timestamp":1768634312727,"version":"3.49.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T00:00:00Z","timestamp":1233792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<i>Background:<\/i> Amino-terminal B-type natriuretic peptide (NT-proBNP) quantification is a useful cardiovascular diagnostic and prognostic test. In renal failure its use may have constraints, as it depends on renal clearance. We aimed to evaluate the clinical usefulness of NT-proBNP in hemodialysis (HD) patients. <i>Methods:<\/i> We measured NT-proBNP levels in 44 patients before and after a regular high-flux HD. Cardiac parameters were evaluated by echocardiography. Patients were followed up for 656.5 \u00b1 476.4 days for the occurrence of hospital admission or death. <i>Results:<\/i> NT-proBNP levels decreased after HD (p < 0.0001) without correlation with ultrafiltration volume, Kt\/V index, weight decrease or pulse pressure decrease. Pre- and post-HD NT-proBNP were similar in patients with and without left ventricular hypertrophy. Pre-HD levels were not significantly associated with prognosis, probably due to a type 2 error; post-HD NT- proBNP and NT-proBNP reduction ratio (RR) were predictive of the outcome by Kaplan-Meier analysis, but only RR remained associated with prognosis on multivariate regression analysis (hazard ratio 0.96; 95% confidence interval 0.93\u20130.99). <i>Conclusion:<\/i> Our results do not support the use of NT-proBNP in the diagnosis of left ventricular hypertrophy or volume status in HD patients, but suggest its utility in prognostic stratification. HD-related variation in NT-proBNP was associated with prognosis.<\/jats:p>","DOI":"10.1159\/000199458","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T13:47:13Z","timestamp":1233755233000},"page":"c182-c188","source":"Crossref","is-referenced-by-count":5,"title":["Aminoterminal B-Type Natriuretic Peptide (NT-proBNP) in End-Stage Renal Failure Patients on Regular Hemodialysis: Does It Have Diagnostic and Prognostic Implications?"],"prefix":"10.1159","volume":"111","author":[{"given":"Joana","family":"Pimenta","sequence":"first","affiliation":[]},{"given":"Francisco","family":"Sampaio","sequence":"additional","affiliation":[]},{"given":"Patr\u00edcia","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Berta","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Rocha-Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Paulo","family":"Bettencourt","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2009,2,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00180516"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2001.0590051928.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2005.08.051"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1026195332025"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1373%2Fclinchem.2004.035741"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5002087"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2362.2007.01785.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1373%2Fclinchem.2003.030692"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000092914"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cca.2006.08.004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.55.4.613"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0735-1097%2892%2990385-Z"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfm700"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1515%2FCCLM.2008.192"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2006.06.056"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cardfail.2007.01.001"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000144310.04433.BE"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS1388-9842%2803%2900098-9"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/199458","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/199458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:29:06Z","timestamp":1745450946000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000199458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,5]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000199458","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,5]]}}}