{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:04:49Z","timestamp":1772456689505,"version":"3.50.1"},"reference-count":9,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Purpose:&lt;\/i&gt; To examine the relationship between microaneurysm turnover (formation rate), using a new semi-automatic method (MA-Tracker) based on color fundus photographs, and diabetic retinopathy (DR) progression to clinically significant macular edema (CSME). &lt;i&gt;Methods:&lt;\/i&gt; In total, 113 patients\/eyes with nonproliferative DR (NPDR) were followed up every 6 months for 2 years as controls of the DR clinical trials, and by conventional general and ophthalmological care for the next 8 years (over a total of 10 years\u2019 follow-up). Microaneurysm turnover for the 2 first years was computed using the MA-Tracker. &lt;i&gt;Results:&lt;\/i&gt; The 17 patients that developed CSME over the 10 years of follow-up presented a microaneurysm formation rate of 9.2 \u00b1 18.2 microaneurysms\/year (mean \u00b1 SD) during the first 2 years, which was statistically higher than the eyes that did not develop CSME (0.5 \u00b1 1.2 microaneurysms\/year, p &lt; 0.001). These 17 patients also presented higher HbA&lt;sub&gt;1C&lt;\/sub&gt; levels at baseline (8.5 \u00b1 1.2%) compared to the patients who did not develop CSME (7.3 \u00b1 1.2%, p = 0.001). &lt;i&gt;Conclusions:&lt;\/i&gt; A high microaneurysm formation rate on color fundus photographs appears to be a good biomarker for DR progression to CSME in type 2 diabetic patients with NPDR.<\/jats:p>","DOI":"10.1159\/000213639","type":"journal-article","created":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T15:36:39Z","timestamp":1240241799000},"page":"292-297","source":"Crossref","is-referenced-by-count":75,"title":["Microaneurysm Turnover Is a Biomarker for Diabetic Retinopathy Progression to Clinically Significant Macular Edema: Findings for Type 2 Diabetics with Nonproliferative Retinopathy"],"prefix":"10.1159","volume":"223","author":[{"given":"Sandrina","family":"Nunes","sequence":"first","affiliation":[]},{"given":"Isabel","family":"Pires","sequence":"additional","affiliation":[]},{"given":"Andreia","family":"Rosa","sequence":"additional","affiliation":[]},{"given":"Lilianne","family":"Duarte","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Bernardes","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Cunha-Vaz","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2009,4,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000098497"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001250051278"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0420.2006.00710.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.80.2.135"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-5491.2008.02505.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2307%2F2529310"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.122.2.211"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.07-1132"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2907019-6"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/213639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/213639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:15:05Z","timestamp":1745446505000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000213639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2009,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000213639","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}