{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:45:59Z","timestamp":1745469959135,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:00:00Z","timestamp":1240531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:00:00Z","timestamp":1240531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<i>Background\/Aims:<\/i> By applying numerical filtering to epidemiological data of 2,512 chronic kidney disease patients, we aimed to identify some of the underlying mechanisms of the calcium\/phosphorus metabolism perturbations. <i>Methods:<\/i> The measured variables, serum calcitriol, calcidiol, total calcium ([Ca]<sub>s<\/sub>) and phosphorus ([P]<sub>s<\/sub>) and the urinary excretions of calcium and phosphorus, were paired in the same patients with the glomerular filtration rate (GFR) or the serum concentrations of parathormone (i[PTH]<sub>s<\/sub>) (used as independent variables) numerically filtered with a moving average and partitioned into 15\u201325 frequency classes. All variables exhibited unimodal frequency distributions. <i>Results:<\/i> There was a steep fall of i[PTH]<sub>s<\/sub>, [P]<sub>s<\/sub>, and urinary excretion fractions of Ca and P up to a value of GFR in the range of 25\u201345 ml\/min\/1.73 m<sup>2<\/sup>. The increase in the phosphorus urinary excretion preceded the steep increase in i[PTH]<sub>s<\/sub>. Except [Ca]<sub>s<\/sub>, all factors exhibited their physiological correlation with i[PTH]<sub>s<\/sub> when GFR was above 90 ml\/min\/1.73 m<sup>2<\/sup> and reverted to a feedback correlation below 80 ml\/min\/1.73 m<sup>2<\/sup>. <i>Conclusion:<\/i> The perturbation of mineral metabolism in chronic kidney disease results in the maintenance of a normal range of [Ca]<sub>s<\/sub> and [P]<sub>s<\/sub> acting as the controlled factors at the cost of large variations of i[PTH]<sub>s<\/sub>, and calcium and phosphate urinary excretions behaving as controlling factors.<\/jats:p>","DOI":"10.1159\/000214208","type":"journal-article","created":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T13:41:27Z","timestamp":1240580487000},"page":"c137-c147","source":"Crossref","is-referenced-by-count":5,"title":["Inferring Disease Mechanisms from Epidemiological Data in Chronic Kidney Disease: Calcium and Phosphorus Metabolism"],"prefix":"10.1159","volume":"112","author":[{"given":"Ana","family":"Pires","sequence":"first","affiliation":[]},{"given":"Teresa","family":"Adrag\u00e3o","sequence":"additional","affiliation":[]},{"given":"Maria Jo\u00e3o","family":"Pais","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Vinhas","sequence":"additional","affiliation":[]},{"given":"Hugo Gil","family":"Ferreira","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2009,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5000414"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfl718"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5002009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2001.28113"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fendo-117-5-2114"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1677%2Fjoe.0.1230137"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.07304.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00336.2004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fendo-110-3-1073"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fendo-110-1-294"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-56-3-572"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fjbmr.5650110714"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200012213432508"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00774-007-0749-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2007010068"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra070553"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-031539"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000081023"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-011870"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/214208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:20:27Z","timestamp":1745446827000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000214208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,24]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000214208","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"type":"electronic","value":"1660-2110"}],"subject":[],"published":{"date-parts":[[2009,4,24]]}}}