{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:11:33Z","timestamp":1777554693824,"version":"3.51.4"},"reference-count":39,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Background:<\/i> This study aimed to characterize the clinicopathological features and prognosis of early onset gastric carcinomas (EOGCs) in a sample of young Portuguese adults. <i>Material and Methods:<\/i> A subset of 415 patients submitted to gastric resection was divided into 2 groups: A \u2013 patients aged 45 years or less (n = 108), and B \u2013 patients older than 45 years (n = 307). The groups were compared for several clinicopathological features and the survival of the patients was analyzed by uni- and multivariate analysis. <i>Results:<\/i> The surgical resection rate was higher in young patients, in whom tumors more frequently displayed an ulcerative shape (p < 0.001) and diffuse\/isolated cell-type histology (p < 0.001). In the elderly, the rate of vascular invasion was significantly higher (p = 0.002). Overall, the survival of young patients was higher than in the elderly (p < 0.001). Survival curves were higher in young patients, except for pT4 and pM1 cases. In the multivariate survival analysis, age (p < 0.001), depth of tumor invasion (p < 0.001), nodal status (p < 0.001), vascular invasion (p = 0.011) and distant metastases (p = 0.007) emerged as independent prognostic factors for gastric carcinoma. <i>Conclusion:<\/i> Young gastric cancer patients no longer present with more advanced disease than the elderly and, overall, survival is better in young patients.<\/jats:p>","DOI":"10.1159\/000219331","type":"journal-article","created":{"date-parts":[[2009,5,20]],"date-time":"2009-05-20T12:26:46Z","timestamp":1242822406000},"page":"215-221","source":"Crossref","is-referenced-by-count":14,"title":["Early Onset Gastric Cancer No Longer Presents as an Advanced Disease with Ominous 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