{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:20:26Z","timestamp":1763036426582,"version":"3.40.4"},"reference-count":35,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T00:00:00Z","timestamp":1247184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T00:00:00Z","timestamp":1247184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<i>Aims:<\/i> To investigate risk factors for progression to microalbuminuria in normoalbuminuric hypertensive patients. <i>Methods:<\/i> In a longitudinal study, 173 previously treated normoalbuminuric hypertensive patients with high cardiovascular risk (70% diabetics) were evaluated at study entry and after 12 months. Levels of urinary albumin excretion (UAE; study entry and end of study) were compared between patients remaining normoalbuminuric (RNA) and progressors to non-normoalbuminuric (NNA) levels. <i>Results:<\/i> Out of 173 patients (59 \u00b1 13 years), 12% evolved to NNA levels. At baseline, NNA and RNA groups did not differ in age, sex, diabetes, lipids, blood pressure (BP), drug therapy, or glomerular filtration rate. In comparison with RNA patients, the NNA group showed higher hypertension duration, greater UAE and percentage of patients with UAE \u226510 mg\/g creatinine (76.2 vs. 45.4%) at study entry and higher BP levels (158\/92 \u00b1 25\/10 vs. 143\/83 \u00b1 20\/12 mm Hg) at study end (all p < 0.05). Logistic regression analysis identified absolute UAE values at study entry and study end variation of BP and cholesterol as independent contributors to the increase in the log odds of developing microalbuminuria. <i>Conclusions:<\/i> Normoalbuminuric hypertensives with UAE within the upper two thirds of normal range are 3 times as likely to develop microalbuminuria after 1 year. A poor BP and lipid control are also associated with increased risk of microalbuminuria.<\/jats:p>","DOI":"10.1159\/000228070","type":"journal-article","created":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T12:23:05Z","timestamp":1247228585000},"page":"c8-c15","source":"Crossref","is-referenced-by-count":7,"title":["Risk Factors for Development of Microalbuminuria in Diabetic and Nondiabetic Normoalbuminuric Hypertensives with High or Very High Cardiovascular Risk \u2013 A Twelve-Month Follow-Up Study"],"prefix":"10.1159","volume":"113","author":[{"given":"Jorge","family":"Cotter","sequence":"first","affiliation":[]},{"given":"Pedro","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Cunha","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Pol\u00f3nia","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2009,7,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00004872-199816090-00014"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.286.4.421"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00004872-200203000-00002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000133312.96477.48"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.105.538132"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F01.hjh.0000209991.48928.c4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa011489"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.09205.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2899%2912323-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa042167"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000154082.72286.2a"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000024416.33113.0A"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000107251.49515.c2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00004872-200306000-00001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9149%2886%2990771-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1191%2F1358863x02vm412ra"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080%2F08037050410016456"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000031732.78052.81"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005121324"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2874%2991002-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jhh.1001316"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1177%2F000331979604701005"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiacare.21.11.1932"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161%2Fhy0302.105209"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.09805.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2002.33906"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097%2F00004872-200203000-00015"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000057855.93268.9F"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfl364"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.07103.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.158.17.1933"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1996.480"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00885.x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2896%2911445-8"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00653.x"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/228070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:36:50Z","timestamp":1745444210000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000228070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,10]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000228070","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"type":"electronic","value":"1660-2110"}],"subject":[],"published":{"date-parts":[[2009,7,10]]}}}