{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T22:14:25Z","timestamp":1759702465646,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[1974,1,1]],"date-time":"1974-01-01T00:00:00Z","timestamp":126230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1974,1,1]],"date-time":"1974-01-01T00:00:00Z","timestamp":126230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[1974]]},"abstract":"<jats:p>Human lymphocytes with receptors for IgG (EA-RFC) were detected in peripheral blood by their ability to form rosettes with human erythrocytes sensitized with human (Ripley anti-CD) or rabbit IgG. EA-RFC were shown to be different from T-lymphocytes forming rosettes with sheep erythrocytes (E-RFC), both by direct studies of mixed rosette suspensions and by separation of EA-RFC and E-RFC by depletion of either EA-RFC or E-RFC by gradient centrifugation of the corresponding rosettes, as well as by fractionation of cells on HSA\/anti-HSA columns, which very effectively and selectively retain EA-RFC. Proportions of EA-RFC were also within the normal range in patients with profound lack of T-cells and were not increased during &lt;i&gt;in vitro &lt;\/i&gt;lymphocyte culture in the presence of T-cell mitogens. The majority of EA-RFC was also distinct from B-lymphocytes as identified by membrane-bound Ig. Thus, EA-RFC could be separated from B-lymphocytes by fractionation on nylon columns retaining B-lymphocytes, but not EA-RFC, by fractionation on HSA\/anti-HSA columns retaining EA-RFC but not B-lymphocytes, as well as by depletion of EA-RFC by gradient centrifugation of rosettes. The correlation between EA-RFC and B-lymphocytes in blood was also very poor, both in patients with pathologically low proportions of either normal or malignant B-lymphocytes as well as with abnormally high proportions. It is therefore concluded that EA-RFC represent a population of lymphocytes largely unrelated to human T- and B-lymphocytes as identified by conventional markers.<\/jats:p>","DOI":"10.1159\/000231207","type":"journal-article","created":{"date-parts":[[2009,7,28]],"date-time":"2009-07-28T06:24:43Z","timestamp":1248762283000},"page":"124-138","source":"Crossref","is-referenced-by-count":112,"title":["Human Lymphocytes with Receptors for IgG"],"prefix":"10.1159","volume":"47","author":[{"given":"S.S.","family":"Fr\u00f8land","sequence":"first","affiliation":[]},{"given":"F.","family":"Wisl\u00f8ff","sequence":"additional","affiliation":[]},{"given":"E.","family":"Michaelsen","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2009,7,23]]},"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/231207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/231207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:08:08Z","timestamp":1745446088000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000231207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000231207","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[1974]]}}}