{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:05:59Z","timestamp":1777867559743,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,11,11]],"date-time":"2009-11-11T00:00:00Z","timestamp":1257897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,11,11]],"date-time":"2009-11-11T00:00:00Z","timestamp":1257897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Addict Res"],"abstract":"<jats:p>Estimates point to the existence of 60,000 heroin-addicted patients in Portugal. In this paper we present a study using a methodology, called sequential combined treatment, based on the following steps: (a) detoxification; (b) family assessment; (c) naltrexone, always administered to the patient by his parents; (d) family intervention and restructuring. Evaluation procedure included sociodemographic data, patient functioning, psychopathological aspects, depression, HIV check and urine sample analysis. Sixty-three heroin-abusing patients consecutively entering the program were studied. 70% of the patients adhered to the method and achieved 35.5 weeks of abstinence. After 1 year of treatment, 40% were still abstinent. Patient functioning and psychopathology also showed considerable improvement. Despite these encouraging results, further studies are necessary to evaluate this method within different groups of heroin addicts.<\/jats:p>","DOI":"10.1159\/000259167","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T11:53:28Z","timestamp":1258113208000},"page":"138-145","source":"Crossref","is-referenced-by-count":2,"title":["Sequential Combined Treatment of Heroin Addicted Patients in Portugal with Naltrexone and Family Therapy"],"prefix":"10.1159","author":[{"given":"Domingos","family":"Neto","sequence":"first","affiliation":[]},{"given":"Miguel","family":"Xavier","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Aguiar","sequence":"additional","affiliation":[]},{"given":"M\u00e1rio","family":"David","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds","family":"Sardinha","sequence":"additional","affiliation":[]},{"given":"Caldas","family":"de Almeida","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2009,11,11]]},"container-title":["European Addiction Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000259167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:27:21Z","timestamp":1777544841000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000259167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000259167","archive":["Portico"],"relation":{},"ISSN":["1022-6877","1421-9891"],"issn-type":[{"value":"1022-6877","type":"print"},{"value":"1421-9891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,11]]}}}