{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:48:43Z","timestamp":1767649723184,"version":"3.40.4"},"reference-count":32,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T00:00:00Z","timestamp":1259020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T00:00:00Z","timestamp":1259020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> A disintegrin and metalloprotein-33 <i>(ADAM33)<\/i> participates in the bronchial remodeling process in asthma, and genetic analyses pointed it out as a candidate gene in asthma. <i>Methods:<\/i> To analyze the association between <i>ADAM33<\/i> and asthma and total and mite-specific IgE levels in a population of the Caribbean Coast of Colombia, we genotyped 6 single-nucleotide polymorphisms of <i>ADAM33<\/i> in 429 asthmatics, 401 controls and 116 family trios using fluorogenic probes. Total and specific IgE against <i>Blomia tropicalis <\/i>and <i>Dermatophagoides pteronyssinus <\/i>were determined by ELISA. Case-control and family-based analyses were performed. Case-control association analyses were corrected by population stratification using a set of 52 ancestry-informative markers. <i>Results:<\/i> Eight common haplotypes were identified; among them, H4 (GCAGGG) was associated with asthma in the family group (Z score: \u20132.049, p = 0.04). We also found an association between the TT genotype of ST+7 and asthma in the case-control study (p = 0.05) that disappeared after correcting for multiple testing. In the family-based analysis, this genotype was a risk factor for asthma (p = 0.01), high total IgE (Z score: 2.546, p = 0.01) and high specific IgE against<i> B. tropicalis<\/i> (p = 0.02) and <i>D. pteronyssinus<\/i> (Z score: 2.414, p = 0.01). V4 was associated with specific IgE against <i>B. tropicalis<\/i> (p = 0.03); T2 with asthma (p = 0.03), high total IgE (p = 0.02) and IgE against D. <i>pteronyssinus<\/i> (p = 0.03) and T1 with high total IgE (p = 0.04). None of these associations was maintained after correction for multiple testing. <i>Conclusions:<\/i> Our findings suggest a relevant role of <i>ADAM33 <\/i>in thepathogenesis of asthma in this population.<\/jats:p>","DOI":"10.1159\/000260081","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T08:38:55Z","timestamp":1259051935000},"page":"32-40","source":"Crossref","is-referenced-by-count":32,"title":["A Six-SNP Haplotype of <i>ADAM33 <\/i>Is Associated with Asthma in a Population of Cartagena, Colombia"],"prefix":"10.1159","volume":"152","author":[{"given":"Candelaria I.","family":"Vergara","sequence":"first","affiliation":[]},{"given":"Nathalie","family":"Acevedo","sequence":"additional","affiliation":[]},{"given":"Silvia","family":"Jim\u00e9nez","sequence":"additional","affiliation":[]},{"given":"Beatriz","family":"Mart\u00ednez","sequence":"additional","affiliation":[]},{"given":"Dilia","family":"Mercado","sequence":"additional","affiliation":[]},{"given":"Leonor","family":"Gusm\u00e3o","sequence":"additional","affiliation":[]},{"given":"Kathleen C.","family":"Barnes","sequence":"additional","affiliation":[]},{"given":"Luis","family":"Caraballo","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2009,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2002.122716"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2961265-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fnature00878"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMcibr022144"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00428-009-0748-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2008.02.031"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0952-7915%2802%2900393-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200801-182OC"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2891%2990252-J"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1996.tb00167.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.1999.00050.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000103221"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fnar%2F16.3.1215"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2F1098-2272%282000%2919%3A1%2B%3C%3A%3AAID-GEPI6%3E3.0.CO%3B2-M"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00439-009-0649-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1086%2F375613"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-1809.2000.6420171.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.2004.018887"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1069424"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2803%2901939-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2004.01977.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200306-877OC"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ejhg.5201662"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.03.035"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200412-1708OC"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2004.1938.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200411-1486OC"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186%2F1465-9921-7-91"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1078311"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.2004.027227"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2006.02471.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2006.02522.x"}],"container-title":["International 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