{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:20:36Z","timestamp":1763036436635,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,11,21]],"date-time":"2009-11-21T00:00:00Z","timestamp":1258761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,11,21]],"date-time":"2009-11-21T00:00:00Z","timestamp":1258761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Introduction:<\/i> Auto-immune pemphigus is an organ-specific immune disorder due to pathogenic auto-antibodies. Both genetic and environmental factors have been associated with the occurrence of auto-immune pemphigus. Little is known about the epidemiology of auto-immune pemphigus in western Europe. <i>Objective:<\/i> To evaluate the incidence of auto-immune pemphigus in south-western France (namely the Midi-Pyr\u00e9n\u00e9es region) in a 5-year period between 2002 and 2006. <i>Materials and Methods:<\/i> We performed a retrospective study of the annual incidence of auto-immune pemphigus diagnosed in the Midi-Pyr\u00e9n\u00e9es region, between January 1, 2002, and December 31, 2006. Possible cases of pemphigus were initially selected using skin direct immunofluorescence (DIF) databases from all laboratories in the Midi-Pyr\u00e9n\u00e9es region. Systematic validation of all cases was performed by two of the authors (N.M., M.T.). To qualify as a case of auto-immune pemphigus, patients had to fulfil the following criteria: history of clinical signs of pemphigus as assessed by a dermatologist and a positive DIF. To be included in the study, validated cases of auto-immune pemphigus had to fulfil the following criteria: the date of first positive skin DIF between January 1, 2002, and December 31, 2006, and patient living in the Midi-Pyr\u00e9n\u00e9es region at the time of the first positive skin DIF. <i>Results:<\/i> Between 2002 and 2006, 91 patients with positive DIF were identified. Fifty-four patients with positive DIF did not meet the validation criteria for the study. Thirty-seven cases were included in the analysis. The crude annual mean incidence of auto-immune pemphigus between 2002 and 2006 was 2.7 cases\/10<sup>6<\/sup> inhabitants\/year (95% CI: 1.87\u20133.69). The world-population-standardized annual mean incidence of auto-immune pemphigus was 1.55 (95% CI: 0.99\u20132.11). <i>Conclusion:<\/i> We report a 1.55\/10<sup>6<\/sup> inhabitants\/year world-population-standardized incidence of auto-immune pemphigus in the south-west of France. A nationwide epidemiological study of pemphigus should be performed in France.<\/jats:p>","DOI":"10.1159\/000261503","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T08:24:56Z","timestamp":1259051096000},"page":"97-102","source":"Crossref","is-referenced-by-count":11,"title":["Incidence of Auto-Immune Pemphigus in the Midi-Pyr\u00e9n\u00e9es Region in 2002\u20132006"],"prefix":"10.1159","volume":"220","author":[{"given":"M.","family":"Thomas","sequence":"first","affiliation":[]},{"given":"C.","family":"Paul","sequence":"additional","affiliation":[]},{"given":"E.","family":"Berard","sequence":"additional","affiliation":[]},{"given":"F.","family":"Fortenfant","sequence":"additional","affiliation":[]},{"given":"J.","family":"Mazereeuw-Hautier","sequence":"additional","affiliation":[]},{"given":"C.","family":"Livideanu","sequence":"additional","affiliation":[]},{"given":"R.","family":"Viraben","sequence":"additional","affiliation":[]},{"given":"N.","family":"Meyer","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2009,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2006.03010.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2004.02533.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080%2F08916930600971497"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2004.02374.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-4362.2000.00864.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4362.1995.tb01563.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12612836"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0030-4220%2874%2990365-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0001-2815.2004.00191.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-4362.2002.01370.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1468-3083.2002.00384.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.humimm.2003.09.019"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep13070394"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.143.7.895"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2006.03044.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2307%2F1403190"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1473-2130.2004.00098.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-4274%2801%2900266-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2F0300-483X%2888%2990019-4"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jid.5700151"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0906-6705.2006.00410.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/261503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/261503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T21:41:01Z","timestamp":1745444461000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000261503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,21]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,3,1]]},"published-print":{"date-parts":[[2010,3,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000261503","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2009,11,21]]}}}