{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T04:04:27Z","timestamp":1767585867679,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Tramadol, a central analgesic acting on serotonin neurotransmission, is often co-used with ondansetron, a 5-HT&lt;sub&gt;3&lt;\/sub&gt; antagonist, for the management of postoperative pain to decrease nausea and vomiting. The aim of the study is to test the hypothesis that this drug combination raises tramadol requirement by patient-controlled analgesia (PCA). Forty patients undergoing hernioplasty or thyroidectomy were enrolled in a randomized, controlled study and allocated to receive ondansetron 4 mg i.v. (n = 20) or saline (n = 20). At 0, 1, 2, 4 and 24 h of PCA, tramadol consumption was evaluated. Tramadol consumption (mg \u00d7 kg&lt;sup&gt;\u20131&lt;\/sup&gt; \u00d7 h&lt;sup&gt;\u20131&lt;\/sup&gt;) was higher in the ondansetron group at the 2-hour time point compared to the control group (0.24 \u00b1 0.1 vs. 0.17 \u00b1 0.16; p = 0.01). Our study suggests that ondansetron acutely reduces the analgesic efficacy of tramadol.<\/jats:p>","DOI":"10.1159\/000330740","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T08:18:07Z","timestamp":1317111487000},"page":"182-187","source":"Crossref","is-referenced-by-count":18,"title":["Co-Administration of Ondansetron Decreases the Analgesic Efficacy of Tramadol in Humans"],"prefix":"10.1159","volume":"88","author":[{"given":"C.","family":"Vale","sequence":"first","affiliation":[]},{"given":"F.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"J.","family":"Assun\u00e7\u00e3o","sequence":"additional","affiliation":[]},{"given":"C.","family":"Fontes-Ribeiro","sequence":"additional","affiliation":[]},{"given":"F.","family":"Pereira","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2011,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2165%2F00003495-200060010-00008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1634%2Ftheoncologist.7-5-424"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1213%2F01.ane.0000295230.55439.f4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00000539-200206000-00033"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00000539-200105000-00045"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpain.2010.03.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1358%2Fmf.2005.27.9.939337"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejpain.2005.10.002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2FBF03020186"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1254%2Fjphs.FP0040153"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2125.1998.00756.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1017%2FS0265021508003645"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330740","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:32:28Z","timestamp":1745433148000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":12,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,10,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000330740","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2011]]}}}