{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:34:34Z","timestamp":1745469274436,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Objectives:<\/i> This study aimed to verify whether human papillomavirus (HPV) testing after conization treatment has some potential usefulness for predicting patients\u2019 outcome. <i>Study Design:<\/i> One hundred and twenty women were treated for HSIL by conization with large loop excision of the transformation zone (LLETZ). Cytology, colposcopy-guided biopsy, and hybrid capture 2 (HC2) HPV DNA tests were performed before the surgical procedure and every 6 months for 2 years at follow-up. <i>Results:<\/i> More than 90% of the patients tested positive for high-risk HPV prior to the surgical intervention. Six months after the cervical conization, 74.75% of the patients tested negative for high-risk HPV DNA, and 19.41% were positive. Of the women who were HC2 negative, 72 showed normal cytological smears, 3 ASC-US, 2 LSIL, and 1 HSIL. Of those who were HC2 positive, 8 showed normal smears, 2 ASC-US, 2 ASC-H, 5 LSIL, and 1 case had HSIL, AGC, and squamous cells invasive carcinoma. Clinically, the HSIL case with a negative HPV test did not show any sign of high-grade lesions, and the clinical follow-up did not show residual lesions. <i>Conclusions:<\/i> Negative HPV tests correlated with freedom from high-grade disease after 2 years of postconization follow-up, which strongly suggests that negative HPV tests predict the absence of cervical disease.<\/jats:p>","DOI":"10.1159\/000330808","type":"journal-article","created":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T15:26:26Z","timestamp":1318260386000},"page":"421-425","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the Combination of Cytology and Hybrid Capture to Safely Predict the High-Grade Lesion Status of Patients Treated with Conization with Large Loop Excision of the Transformation Zone"],"prefix":"10.1159","volume":"55","author":[{"given":"Maria Teresa","family":"Roncaglia","sequence":"first","affiliation":[]},{"given":"Maricy","family":"Tacla","sequence":"additional","affiliation":[]},{"given":"Eduardo","family":"Vieira da Motta","sequence":"additional","affiliation":[]},{"given":"H\u00e9lio","family":"Caiaffa","sequence":"additional","affiliation":[]},{"given":"Alexandre","family":"Ab\u2019Saber","sequence":"additional","affiliation":[]},{"given":"Ven\u00e2ncio Avancini Ferreira","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Adhemar","family":"Longatto Filho","sequence":"additional","affiliation":[]},{"given":"Edmund C.","family":"Baracat","sequence":"additional","affiliation":[]}],"member":"127","published-online":{"date-parts":[[2011,10,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322%2Fcanjclin.55.2.74"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F87.11.796"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.325.7364.572"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2898%2912490-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-0528.1989.tb03380.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-0528.1997.tb11983.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jcv.2004.05.012"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-0528.2006.01063.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00006254-200407000-00024"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F91.3.252"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2898%2900246-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0020-7292%2899%2900162-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2FIGC.0b013e3181a834fe"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2008.11.031"}],"container-title":["Acta Cytologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/330808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:33:09Z","timestamp":1745433189000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000330808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,10,1]]},"published-print":{"date-parts":[[2011,10,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000330808","archive":["Portico"],"relation":{},"ISSN":["0001-5547","1938-2650"],"issn-type":[{"type":"print","value":"0001-5547"},{"type":"electronic","value":"1938-2650"}],"subject":[],"published":{"date-parts":[[2011]]}}}